Literature DB >> 500206

Arabinosylthymine: inhibitor of splenic lymphocyte macromolecular synthesis in vitro.

J M Barnett, J J McGowan, G A Gentry.   

Abstract

The effect of arabinosylthymine on lymphocyte transformation was investigated. Arabinosylthymine was demonstrated not to be cytotoxic for hamster spleen lymphocytes but was found to inhibit the increase in deoxyribonucleic acid and protein synthesis usually observed as a result of mitogen stimulation. These findings suggest that, in addition to being a potent anti-herpesvirus inhibitor, arabinosylthymine is also an immunosuppressive agent.

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Year:  1979        PMID： 500206      PMCID： PMC414610          DOI： 10.1128/iai.26.1.294-297.1979

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  8 in total

1.  Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia.

Authors:  L S Lee; Y C Cheng
Journal:  J Biol Chem       Date:  1976-05-10       Impact factor: 5.157

2.  Inhibition of herpes simplex virus replication by araT.

Authors:  G A Gentry; J F Aswell
Journal:  Virology       Date:  1975-05       Impact factor: 3.616

3.  Purification and characterization of deoxythymidine kinase (dTK) induced in dTK- 3T3 mouse cells by equine herpesvirus type 1 (EHV-1).

Authors:  G P Allen; J J McGowan; C C Randall; W Mancini; Y C Cheng; G A Gentry
Journal:  Virology       Date:  1979-01-30       Impact factor: 3.616

4.  Brain-associated thymic antigen in chickens.

Authors:  J M Barnett; B Glick
Journal:  Int Arch Allergy Appl Immunol       Date:  1977

5.  Deoxythymidine kinase induced in HeLa TK- cells by herpes simplex virus type I and type II. II. Purification and characterization.

Authors:  Y C Cheng; M Ostrander
Journal:  J Biol Chem       Date:  1976-05-10       Impact factor: 5.157

6.  Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.

Authors:  J F Aswell; G P Allen; A T Jamieson; D E Campbell; G A Gentry
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

7.  Arabinosyl nucleosides. XIII. Influence of arabinofuranosylthymine on DNA-, RNA- and protein-synthesizing systems in vitro.

Authors:  W E Müller; R K Zahn; J Arendes
Journal:  Chem Biol Interact       Date:  1978-11       Impact factor: 5.192

8.  Inhibitory effect of 1-beta-D-arabinofuranosylthymine 5'-triphosphate and 1-beta-D-arabinofuranosylcytosine 5'-triphosphate on DNA polymerases from murine cells and oncornavirus.

Authors:  A Matsukage; K Ono; A Ohashi; T Takahashi; C Nakayama; M Saneyoshi
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701
  8 in total
  2 in total

1.  Biochemical characterization of equine herpesvirus type 3-induced deoxythymidine kinase purified from lytically infected horse embryo dermal fibroblasts.

Authors:  J J McGowan; G P Allen; J M Barnett; G A Gentry
Journal:  J Virol       Date:  1980-05       Impact factor: 5.103

2.  Arabinosylthymine: suppressor of hamster immunoglobulin M formation during primary immune response.

Authors:  J M Barnett; J J McGowan; G A Gentry
Journal:  Infect Immun       Date:  1980-04       Impact factor: 3.441
  2 in total

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