Literature DB >> 4997759

Serological and structural properties of Mason-Pfizer monkey virus isolated from the mammary tumor of a Rhesus monkey.

R C Nowinski, E Edynak, N H Sarkar.   

Abstract

We describe here serological and structural properties of a virus, Mason-Pfizer Monkey Virus (M-PMV), isolated from a simian mammary tumor. This virus is morphologically similar to the known oncogenic RNA viruses (oncornaviruses). It has a 60-70S RNA, and its replication is inhibited by actinomycin. Antisera prepared against the virus isolated by density-gradient centrifugation identify at least two viral structural antigens. Immunodiffusion studies show that this virus is serologically unrelated to three types of simian foamy viruses, visna virus, and the known oncornaviruses. Immunofluorescence reveals that the structural proteins of the virus are synthesized cytoplasmically. Although M-PMV productively infects human cells in vitro, serological analysis does not show the presence of M-PMV antigens in human neoplasia.

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Year:  1971        PMID： 4997759      PMCID： PMC389251          DOI： 10.1073/pnas.68.7.1608

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  DNA-directed DNA polymerase activity in oncogenic RNA viruses.

Authors:  S Spiegelman; A Burny; M R Das; J Keydar; J Schlom; M Travnicek; K Watson
Journal:  Nature       Date:  1970-09-05       Impact factor: 49.962

2.  Shared viral antigen of mammalian leukaemia viruses.

Authors:  G Geering; T Aoki; L J Old
Journal:  Nature       Date:  1970-04-18       Impact factor: 49.962

3.  Association of herpes-like virus infection with infectious mononucleosis.

Authors:  Y Hirshaut; P Glade; H Moses; R Manaker; L Chessin
Journal:  Am J Med       Date:  1969-10       Impact factor: 4.965

4.  A new virus in a spontaneous mammary tumor of a rhesus monkey.

Authors:  H C Chopra; M M Mason
Journal:  Cancer Res       Date:  1970-08       Impact factor: 12.701

5.  A soluble antigen of the mammary tumor virus.

Authors:  R C Nowinski; L J Old; D H Moore; G Geering; E A Boyse
Journal:  Virology       Date:  1967-01       Impact factor: 3.616

6.  Common properties of the oncogenic RNA viruses (oncornaviruses).

Authors:  R C Nowinski; L J Old; N H Sarkar; D H Moore
Journal:  Virology       Date:  1970-12       Impact factor: 3.616

7.  Visna virus: a slow virus with an RNA dependent DNA polymerase.

Authors:  L B Stone; E Scolnick; K K Takemoto; S A Aaronson
Journal:  Nature       Date:  1971-01-22       Impact factor: 49.962

8.  DNA polymerase activities in varions of visna virus, a causative agent of a "slow" neurological disease.

Authors:  J Schlom; D H Harter; A Burny; S Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1971-01       Impact factor: 11.205

9.  Feline leukemia virus: occurrence of viral antigen in the tissues of cats with lymphosarcoma and other diseases.

Authors:  W D Hardy; G Geering; L J Old; E DE Harven; R S Brody; S McDonough
Journal:  Science       Date:  1969-11-21       Impact factor: 47.728

10.  Murine sarcoma virus transformation of BALB-3T3 cells: lack of dependence on murine leukemia virus.

Authors:  S A Aaronson; J L Jainchill; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205
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  13 in total

1.  Mason-Pfizer virus RNA genome: relationship to the RNA of morphologically similar isolates and other oncornaviruses.

Authors:  D Colcher; W Drohan
Journal:  J Virol       Date:  1976-03       Impact factor: 5.103

2.  Separation of B and C type virions by centrifugation in gentle density gradients.

Authors:  N H Sarkar; D H Moore
Journal:  J Virol       Date:  1974-05       Impact factor: 5.103

3.  Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses.

Authors:  W P Parks; E M Scolnick; J Ross; G J Todaro; S A Aaronson
Journal:  J Virol       Date:  1972-01       Impact factor: 5.103

4.  Synthesis of DNA complements of natural RNAs: a general approach.

Authors:  S Spiegelman; K F Watson; D L Kacian
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

5.  DNA polymerase activities and nucleic acid components of virions isolated from a spontaneous mammary carcinoma from a rhesus monkey.

Authors:  J Schlom; S Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1971-07       Impact factor: 11.205

6.  RNA subunit structure of Mason-Pfizer monkey virus.

Authors:  G Schochetman; J Schlom
Journal:  J Virol       Date:  1975-02       Impact factor: 5.103

7.  Sequence homology between the RNA of Mason-Pfizer monkey virus and the RNA of human malignant breast tumors.

Authors:  D Colcher; S Spiegelman; J Schlom
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

8.  Effect of monensin on Mason-Pfizer monkey virus glycoprotein synthesis.

Authors:  S Chatterjee; J A Bradac; E Hunter
Journal:  J Virol       Date:  1982-12       Impact factor: 5.103

9.  Immunological properties of two polypeptides of Mason-Pfizer monkey virus.

Authors:  S R Tronick; J R Stephenson; S A Aaronson
Journal:  J Virol       Date:  1974-07       Impact factor: 5.103

10.  Purification, characterization, and comparison of the DNA polymerases from two primate RNA tumor viruses.

Authors:  J W Abrell; R C Gallo
Journal:  J Virol       Date:  1973-09       Impact factor: 5.103
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