Literature DB >> 4996593

Teratogenic effects of a chelating agent and their prevention by zinc.

H Swenerton, L S Hurley.   

Abstract

Ingestion of a chelating agent (ethylenediaminetetraacetic acid) by female rats during pregnancy impaired reproduction and resulted in congenitally malformed young. When ethylenediaminetetraacetic acid was fed from days 6 to 21 of gestation, all of the full-term young had gross congenital malformations. These effects were prevented by simultaneous supplementation with 1000 parts per million of dietary zinc.

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Year:  1971        PMID： 4996593     DOI： 10.1126/science.173.3991.62

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  Chelation therapy.

Authors:  P C Carven; H F Morrelli
Journal:  West J Med       Date:  1975-03

2.  Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents.

Authors:  A G Braun; C A Buckner; D J Emerson; B B Nichinson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

3.  The implications of trace metal-nitrilotriacetetic acid speciation on its environmental impact and toxicology.

Authors:  M Rubin; A E Martell
Journal:  Biol Trace Elem Res       Date:  1980-03       Impact factor: 3.738

4.  Dimethoxyethyl phthalate: embryopathy, teratogenicity, fetal metabolism and the role of zinc in the rat.

Authors:  M R Parkhie; M Webb; M A Norcross
Journal:  Environ Health Perspect       Date:  1982-11       Impact factor: 9.031

Review 5.  Reasons for raising the maximum acceptable daily intake of EDTA and the benefits for iron fortification of foods for children 6-24 months of age.

Authors:  Carel Theo Jozef Wreesmann
Journal:  Matern Child Nutr       Date:  2014-02-13       Impact factor: 3.092
  5 in total

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