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Literature DB >> 499437

Ectopic human chorionic gonadotropin in breast carcinoma.

A Castro, P Buschbaum, M Nadji, W Voigt, S Tabei, A Morales.

Abstract

Immunoreactive human chorionic gonadotropin (hCG) was found in 9 of 65 surgically removed malignant breast tumors. Concentrations ranged from 5 to greater than 500 mIU hCG/g tumor. hCG was measured by a beta-chain specific readiommunoassay. In further study of these specimens, an immunoperoxidase staining technique was used to stain for hCG in formalin-fixed sections. The hCG was shown to be localized within the cytoplasm and on the surface of the malignant cells.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 499437 DOI： 10.1007/bf01964028

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

12 in total

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Authors: F J Morgan; S Birken; R E Canfield
Journal: J Biol Chem Date: 1975-07-10 Impact factor: 5.157

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Authors: D C Tormey; T P Waalkes; R M Simon
Journal: Cancer Date: 1977-06 Impact factor: 6.860

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Authors: G D Braunstein; J L Vaitukaitis; P P Carbone; G T Ross
Journal: Ann Intern Med Date: 1973-01 Impact factor: 25.391

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Authors: J L Vaitukaitis; G D Braunstein; G T Ross
Journal: Am J Obstet Gynecol Date: 1972-07-15 Impact factor: 8.661

10. Evidence for a gonadotropin from nonpregnant subjects that has physical, immunological, and biological similarities to human chorionic gonadotropin.

Authors: H C Chen; G D Hodgen; S Matsuura; L J Lin; E Gross; L E Reichert; S Birken; R E Canfield; G T Ross
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

Ectopic human chorionic gonadotropin in breast carcinoma.

1. The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.

2. Biological markers in breast carcinoma. II. Clinical correlations with human chorionic gonadotrophin.

3. Ectopic production of human chorionic gonadotrophin by neoplasms.

4. A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone.

Review 5. Gonadotropins and their subunits: basic and clinical studies.

6. Immunoperoxidase techniques: practical and theoretical aspects.

Review 7. Studies of human chorionic gonadotropin.

8. Presence in normal human testes of a chorionic-gonadotropin-like substance distinct from human luteinizing hormone.

9. Carcinoembryonic antigen in histopathology: immunoperoxidase staining of conventional tissue sections.

10. Evidence for a gonadotropin from nonpregnant subjects that has physical, immunological, and biological similarities to human chorionic gonadotropin.