Literature DB >> 499426

The principal toxin of Delphinium brownii Rydb., and its mode of action.

V N Aiyar, M H Benn, T Hanna, J Jacyno, S H Roth, J L Wilkens.   

Abstract

Examination of D. brownii, a stock-poison of Western Canada, revealed that the principal toxin was methyllycaconitine: a potent neuromuscular blocking agent which appears to act competitively at nicotinic receptors.

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Year:  1979        PMID： 499426     DOI： 10.1007/bf01964013

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

Review 1.  Toxins and teratogens of higher plants.

Authors:  R F Keeler
Journal:  Lloydia       Date:  1975 Jan-Feb

2.  Observations on the isolated phrenic nerve diaphragm preparation of the rat.

Authors:  E BULBRING
Journal:  Br J Pharmacol Chemother       Date:  1946-03

3.  Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model.

Authors:  W A Catterall
Journal:  J Biol Chem       Date:  1977-12-10       Impact factor: 5.157

4.  The permeability of aconitine-modified sodium channels to univalent cations in myelinated nerve.

Authors:  G N Mozhayeva; A P Naumov; Y A Negulyaev; E D Nosyreva
Journal:  Biochim Biophys Acta       Date:  1977-05-02

5.  The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.

Authors:  W D PATON
Journal:  Br J Pharmacol Chemother       Date:  1957-03
  5 in total
  10 in total

1.  Immobilization with atrophy induces de novo expression of neuronal nicotinic α7 acetylcholine receptors in muscle contributing to neurotransmission.

Authors:  Sangseok Lee; Hong-Seuk Yang; Tomoki Sasakawa; Mohammed A S Khan; Ashok Khatri; Masao Kaneki; J A Jeevendra Martyn
Journal:  Anesthesiology       Date:  2014-01       Impact factor: 7.892

2.  Glutamate and GABA release are enhanced by different subtypes of presynaptic nicotinic receptors in the lateral geniculate nucleus.

Authors:  J Z Guo; T L Tredway; V A Chiappinelli
Journal:  J Neurosci       Date:  1998-03-15       Impact factor: 6.167

3.  Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.

Authors:  F Ivy Carroll; Wei Ma; Hernán A Navarro; Philip Abraham; Scott A Wolckenhauer; M I Damaj; Billy R Martin
Journal:  Bioorg Med Chem       Date:  2006-11-01       Impact factor: 3.641

4.  Mineral-salt supplementation to ameliorate larkspur poisoning in cattle.

Authors:  Clinton A Stonecipher; Ben T Green; Kevin D Welch; Dale R Gardner; Scott A Fritz; Daniel Cook; James A Pfister
Journal:  J Anim Sci       Date:  2022-05-01       Impact factor: 3.338

Review 5.  Nicotinic agonists, antagonists, and modulators from natural sources.

Authors:  John W Daly
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

6.  The biogeographical distribution of duncecap larkspur (Delphinium occidentale) chemotypes and their potential toxicity.

Authors:  Daniel Cook; Dale R Gardner; James A Pfister; Kevin D Welch; Benedict T Green; Stephen T Lee
Journal:  J Chem Ecol       Date:  2009-05-21       Impact factor: 2.626

7.  Clinical signs and studies of the site of action of purified larkspur alkaloid, methyllycaconitine, administered parenterally to calves.

Authors:  P N Nation; M H Benn; S H Roth; J L Wilkens
Journal:  Can Vet J       Date:  1982-09       Impact factor: 1.008

8.  Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists.

Authors:  Gretchen Y López-Hernández; Jeffrey S Thinschmidt; Guangrong Zheng; Zhenfa Zhang; Peter A Crooks; Linda P Dwoskin; Roger L Papke
Journal:  Mol Pharmacol       Date:  2009-06-25       Impact factor: 4.436

Review 9.  From toxins targeting ligand gated ion channels to therapeutic molecules.

Authors:  Adak Nasiripourdori; Valérie Taly; Thomas Grutter; Antoine Taly
Journal:  Toxins (Basel)       Date:  2011-03-21       Impact factor: 4.546

Review 10.  Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors.

Authors:  Roger L Papke; Nicole A Horenstein
Journal:  Pharmacol Rev       Date:  2021-07       Impact factor: 18.923
  10 in total

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