Literature DB >> 4993338

Mode of action of streptozotocin.

F Reusser.   

Abstract

Streptozotocin induces rapid degradation of deoxyribonucleic acid (DNA) in actively dividing or resting Bacillus subtilis cells. Difference spectroscopy showed that the antibiotic interacts specifically with cytosine containing mononucleotides in vitro. This interference occurs only within the very narrow pH range of 5 to 5.5 and is reversed immediately upon lowering or increasing the pH. No measurable interaction was observed between isolated DNA and streptozotocin. The possibility is discussed that interaction of streptozotocin with cytosine residues in cellular DNA, although possibly taking place at a very low frequency, may constitute the primary step inducing DNA strand breakage.

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Year:  1971        PMID： 4993338      PMCID： PMC248427          DOI： 10.1128/jb.105.2.580-588.1971

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  The effects of nucleases on the reproduction of T3 bacteriophage in protoplasts of Escherichia coli.

Authors:  D FRASER; H R MAHLER
Journal:  Arch Biochem Biophys       Date:  1957-07       Impact factor: 4.013

2.  THE INFECTION OF SUB-CELLULAR ESCHERICHIA COLI, STRAIN B, WITH A DNA PREPARATION FROM T2 BACTERIOPHAGE.

Authors:  D Fraser; H R Mahler; A L Shug; C A Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1957-11-15       Impact factor: 11.205

3.  On the mechanism of action of antibiotic U-19,718 in rat liver mitochondria.

Authors:  F Reusser
Journal:  Biochemistry       Date:  1968-01       Impact factor: 3.162

4.  Differences in the action of nitrosomethylurea and streptozotocin.

Authors:  H S Rosenkranz; H S Carr
Journal:  Cancer Res       Date:  1970-01       Impact factor: 12.701

5.  Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

Authors:  R Okazaki; T Okazaki; K Sakabe; K Sugimoto; A Sugino
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205

6.  On the inhibition of ribonucleic synthesis in Bacillus subtilis cells by steffimycin.

Authors:  F Reusser
Journal:  Biochem Pharmacol       Date:  1968-09       Impact factor: 5.858

7.  Strong mutagenic activity of streptozotocin--an antibiotic with an alkylnitroso group.

Authors:  T Gichner; J Velemínský; J Krepinský
Journal:  Mol Gen Genet       Date:  1968

8.  The structure of streptozotocin.

Authors:  R R Herr; J K Jahnke; A D Argoudelis
Journal:  J Am Chem Soc       Date:  1967-08-30       Impact factor: 15.419

9.  Mode of action of melinacidin, an inhibitor of nicotinic acid biosynthesis.

Authors:  F Reusser
Journal:  J Bacteriol       Date:  1968-10       Impact factor: 3.490
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  11 in total

Review 1.  The role of antitumor antibiotics in current oncologic practice.

Authors:  H L Davis; D D von Hoff; J E Henney; M Rozencweig
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

2.  Phosphorylation of streptozotocin during uptake via the phosphoenolpyruvate: sugar phosphotransferase system in Escherichia coli.

Authors:  J Ammer; M Brennenstuhl; P Schindler; J V Höltje; H Zähner
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

3.  Widespread N-acetyl-D-glucosamine uptake among pelagic marine bacteria and its ecological implications.

Authors:  Lasse Riemann; Farooq Azam
Journal:  Appl Environ Microbiol       Date:  2002-11       Impact factor: 4.792

4.  Streptozotocin effective for treating multiple-hormone-producing malignant islet cell tumor.

Authors:  E Murata; S Tashiro; T Hiraoka
Journal:  Jpn J Surg       Date:  1985-01

5.  The synthesis of [14C] streptozotocin and its distribution and excretion in the rat.

Authors:  E H Karunanayake; D J Hearse; G Mellows
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

6.  Mode of action of zorbamycin.

Authors:  F Reusser
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490

7.  Analysis of the physiological effects of the antibiotic streptozotocin on Escherichia coli K 12 and other sensitive bacteria.

Authors:  J Lengeler
Journal:  Arch Microbiol       Date:  1980-12       Impact factor: 2.552

8.  Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy.

Authors:  Changrun Guo; Gang Ding; Wenzhe Huang; Zhenzhong Wang; Zhaoqing Meng; Wei Xiao
Journal:  Drug Des Devel Ther       Date:  2016-02-24       Impact factor: 4.162

9.  1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol Attenuates Streptozotocin-Induced Pancreatic Beta Cell Damage by Promoting Glucose Transporter 2 Endocytosis.

Authors:  Jimin Kim; Joo Heon Kim; Ki-Young Sohn; Sun Young Yoon; Jae Wha Kim
Journal:  Mol Cell Biol       Date:  2019-10-11       Impact factor: 4.272

10.  Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells.

Authors:  Ji Zhang; Liubov Yakovlieva; Bart J de Haan; Paul de Vos; Adriaan J Minnaard; Martin D Witte; Marthe T C Walvoort
Journal:  Antibiotics (Basel)       Date:  2020-04-15
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