Literature DB >> 4991924

Sterility test method for petrolatum-based ophthalmic ointments.

K Tsuji, E M Stapert, J H Robertson, P M Waiyaki.   

Abstract

A sensitive sterility testing procedure for the detection of microbial contamination in petrolatum-based ointments is described. The method involves dissolving the ointment in filter-sterilized isopropyl myristate and filtering through a membrane filter. Improved sensitivity is obtained by blending the membrane in Trypticase Soy Broth before incubation. Filter-sterilized isopropyl myristate is shown to be less toxic to microorganisms than heat-sterilized isopropyl myristate. The isopropyl myristate method is more sensitive than the polyethylene glycol-ether method for the detection of microbial contamination.

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Year:  1970        PMID： 4991924      PMCID： PMC377050          DOI： 10.1128/am.20.5.798-801.1970

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  6 in total

1.  IMPROVED VIABLE COUNTING METHOD FOR PETROLATUM-BASED OINTMENTS.

Authors:  W T SOKOLSKI; C G CHIDESTER
Journal:  J Pharm Sci       Date:  1964-01       Impact factor: 3.534

2.  Application of Statistics to Problems in Bacteriology: I. A Means of Determining Bacterial Population by the Dilution Method.

Authors:  H O Halvorson; N R Ziegler
Journal:  J Bacteriol       Date:  1933-02       Impact factor: 3.490

3.  Microbial content in non-sterile pharmaceuticals. II. Methods.

Authors:  E A Pedersen; L Szabo
Journal:  Dan Tidsskr Farm       Date:  1968

4.  Method for microbiological testing of nonsterile pharmaceuticals.

Authors:  X Bühlmann
Journal:  Appl Microbiol       Date:  1968-12

5.  Microbiological contamination of medical preparations.

Authors:  L O Kallings; O Ringertz; L Silverstolpe
Journal:  Acta Pharm Suec       Date:  1966-06

6.  Fine structure of millipore filters.

Authors:  B Friedman; P Blais; P Shaffer
Journal:  J Cell Biol       Date:  1968-10       Impact factor: 10.539
  6 in total
  1 in total

1.  Microcount method for petrolatum-based topical ointments containing waxes.

Authors:  K Tsuji; J H Robertson
Journal:  Appl Microbiol       Date:  1970-11
  1 in total

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