Literature DB >> 4990920

Intrathecal chemotherapy. Selection of cytostatic agents.

T Hayakawa, R Yamada, N Kanai, R Kuroda, Y Ushio, H Higashi, H Mogami.   

Abstract

Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of various cytostatic agents. As a result, it may be concluded that Methotrexate and Endoxan and lower dose of mitomycin C are suitable drugs for intrathecal chemotherapy.Based on these findings, clinical cases of malignant brain tumours were treated with intrathecal chemotherapy.Grateful acknowledgement is made to Professor Dennosuke Jinnai for his constant interest and guidance in this investigation.

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Year:  1970        PMID： 4990920      PMCID： PMC2008617          DOI： 10.1038/bjc.1970.59

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  11 in total

1.  Intrathecal aminopterin therapy of meningeal leukemia.

Authors:  R E RIESELBACH; E E MORSE; D P RALL; E FREI; E J FREIREICH
Journal:  Arch Intern Med       Date:  1963-05

2.  [On the local application of cytostatic substances in the brain].

Authors:  F HEPPNER; H E DIEMATH; F L JENKNER
Journal:  Wien Med Wochenschr       Date:  1961-11-04

3.  Intrathecal amethopterin in neurological manifestations of leukemia.

Authors:  J A WHITESIDE; F S PHILIPS; H W DARGEON; J H BURCHENAL
Journal:  AMA Arch Intern Med       Date:  1958-02

4.  Pharmacology of folic acid antagonists as related to brain and cerebrospinal fluid.

Authors:  D P RALL; R E RIESELBACH; V T OLIVERIO; E MORSE
Journal:  Cancer Chemother Rep       Date:  1962-02

5.  Experience with the subcutaneous cerebrospinal-fluid reservoir. Preliminary report of 60 cases.

Authors:  R A Ratcheson; A K Ommaya
Journal:  N Engl J Med       Date:  1968-11-07       Impact factor: 91.245

6.  Experimental studies of the chemotherapy of brain tumors. 1. Distribution of cytostatic agents in the serum, cerebrospinal fluid and brain tissue after intravenous, intracarotid and intrathecal administration.

Authors:  R Yamada; N Kanai; R Kuroda; T Hayakawa; H Higashi
Journal:  Med J Osaka Univ       Date:  1968-03

7.  Cerebrospinal fluid perfusion for central nervous system neoplasms.

Authors:  R C Rubin; A K Ommaya; E S Henderson; E A Bering; D P Rall
Journal:  Neurology       Date:  1966-07       Impact factor: 9.910

8.  Effects of intracisternal vinblastine in dogs.

Authors:  A A Hockey; J Mealey
Journal:  Surg Forum       Date:  1965

9.  Conference on obstacles to the control of acute leukemia. Experimental studies of the blood-brain barrier.

Authors:  D P Rall
Journal:  Cancer Res       Date:  1965-10       Impact factor: 12.701

10.  Effects of mitomycin-C on HeLa cells at the various stages of division cycle.

Authors:  O Doi; S Takai; Y Aoki; H Higashi; G Kosaki
Journal:  Gan       Date:  1967-04
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  2 in total

1.  ACNU, MTX and 5-FU penetration of rat brain tissue and tumors.

Authors:  T Y Huang; N Arita; T Hayakawa; Y Ushio
Journal:  J Neurooncol       Date:  1999       Impact factor: 4.130

Review 2.  Interstitial chemotherapy for brain tumors: review.

Authors:  T Tomita
Journal:  J Neurooncol       Date:  1991-02       Impact factor: 4.130
  2 in total

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