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Literature DB >> 4990379

Changes in gut flora after cephalexin treatment.

Abstract

Eighteen patients with urinary tract infection were treated with cephalexin orally. Absorption was variable, between 29 and 89% of the total daily dose being excreted in the urine in 24 hours. A significant number of patients became faecal carriers of Pseudomonas aeruginosa compared with a control group who received no antibiotics. Four of the cephalexin-treated patients acquired a strain of Ps. aeruginosa known to be present in food from the hospital diet kitchen and one developed a urinary tract infection with this strain.

Entities: Chemical Disease Species

Mesh：

Substances：
Cephalosporins

Year: 1970 PMID： 4990379 PMCID： PMC1701693 DOI： 10.1136/bmj.3.5723.624

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

6 in total

1. Food and medicaments as possible sources of hospital strains of Pseudomonas aeruginosa.

Authors: R A Shooter; H Gaya; E M Cooke; P Kumar; N Patel; M T Parker; B T Thom; D R France
Journal: Lancet Date: 1969-06-21 Impact factor: 79.321

2. Cephalexin: microbiological effects and pharmacologic parameters in man.

Authors: B R Meyers; K Kaplan; L Weinstein
Journal: Clin Pharmacol Ther Date: 1969 Nov-Dec Impact factor: 6.875

3. Clinical and in vitro evaluation of cephalexin. A new orally administered cephalosporin antibiotic.

Authors: M E Levison; W D Johnson; T S Thornhill; D Kaye
Journal: JAMA Date: 1969-09-01 Impact factor: 56.272

4. Laboratory and clinical experience with cephalexin.

Authors: A C Kind; D G Kestle; H C Standiford; W M Kirby
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1968

5. Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic.

Authors: P E Gower; C H Dash
Journal: Br J Pharmacol Date: 1969-11 Impact factor: 8.739

6. Faecal carriage of Pseudomonas aeruginosa in hospital patients. Possible spread from patient to patient.

Authors: R A Shooter; K A Walker; V R Williams; G M Horgan; M T Parker; E H Asheshov; J F Bullimore
Journal: Lancet Date: 1966-12-17 Impact factor: 79.321

6 in total

8 in total

1. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment.

Authors: W Brumfitt; I Franklin; D Grady; J M Hamilton-Miller
Journal: Antimicrob Agents Chemother Date: 1986-08 Impact factor: 5.191

Changes in gut flora after cephalexin treatment.

1. Food and medicaments as possible sources of hospital strains of Pseudomonas aeruginosa.

2. Cephalexin: microbiological effects and pharmacologic parameters in man.

3. Clinical and in vitro evaluation of cephalexin. A new orally administered cephalosporin antibiotic.

4. Laboratory and clinical experience with cephalexin.

5. Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic.

6. Faecal carriage of Pseudomonas aeruginosa in hospital patients. Possible spread from patient to patient.

1. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment.

2. Colonization resistance of the digestive tract of mice during systemic antibiotic treatment.

Review 3. Cephalexin: a review of its antibacterial, pharmacological and therapeutic properties.

4. Multiple-dose pharmacokinetics of ceftazidime and its influence on fecal flora.

Review 5. Antimicrobial prophylaxis in the neutropenic host: lessons of the past and perspectives for the future.

6. Pseudomonas aeruginosa and Klebsiella pneumoniae on the perinea of males with spinal cord injuries.

7. Effect of broad-spectrum parenteral antibiotics on "colonization resistance" of intestinal microflora of humans.

Review 8. Role of cephalosporins in the era of Clostridium difficile infection.