Literature DB >> 4986218

Soluble antigens obtained from influenza virus by treatment with non-ionic detergent.

M J Corbel, C J Rondle.   

Abstract

Highly purified influenza virus was degraded using anionic and non-ionic detergents. Best results were obtained using the non-ionic detergent Triton N 101. Tests showed that virus extracts contained neuraminidase and a substance that reacted specifically with rabbit antibody to virus haemagglutinin (specific serum blocking substance). Haemagglutination-inhibiting antibody was produced when virus extracts were inoculated into guinea-pigs. Immunodiffusion tests showed that extracts were complex. Host-specific material was regularly found. Under appropriate conditions S-antigen was detected as a single line pattern component. Two or more virus-specific materials were also present. One of these was probably neuraminidase and the other the specific serum blocking substance.

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Year:  1970        PMID： 4986218      PMCID： PMC2130777          DOI： 10.1017/s0022172400028539

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN： 0022-1724


  31 in total

1.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

2.  ASSOCIATION OF MYXOVIRUSES WITH AN ADENOSINE DIPHOSPHATASE/ADENOSINE TRIPHOSPHATASE/AS REVEALED BY CHROMATOGRAPHY ON DEAE-CELLULOSE AND BY DENSITY GRADIENT CENTRIFUGATION.

Authors:  A R NEURATH; F SOKOL
Journal:  Z Naturforsch B       Date:  1963-12       Impact factor: 1.047

3.  Antigenic analysis of influenza viruses by complement fixation. II. The production of antisera to strain-specific V antigens in guinea pigs.

Authors:  A FABIYI; F S LIEF; W HENLE
Journal:  J Immunol       Date:  1958-12       Impact factor: 5.422

4.  Antigenic analyses of influenza viruses by complement fixation. I. The production of antibodies to the soluble antigen in guinea pigs.

Authors:  F S LIEF; A FABIYI; W HENLE
Journal:  J Immunol       Date:  1958-01       Impact factor: 5.422

5.  A slide microtechnique for the analysis of immune precipitates in gel.

Authors:  C WADSWORTH
Journal:  Int Arch Allergy Appl Immunol       Date:  1957

6.  Antigen-antibody precipitates in solid medium with influenza virus.

Authors:  K E JENSEN; T FRANCIS
Journal:  J Immunol       Date:  1953-03       Impact factor: 5.422

7.  Structure of the influenza virus; the relation between biological activity and chemical structure of virus fractions.

Authors:  L HOYLE
Journal:  J Hyg (Lond)       Date:  1952-06

8.  Immunochemical study of influenza virus and associated host tissue components.

Authors:  C Howe; L T Lee; A Harboe; G Haukenes
Journal:  J Immunol       Date:  1967-03       Impact factor: 5.422

9.  Immunodiffusion reaction with influenza virus haemagglutinin.

Authors:  S Ivanicová
Journal:  Acta Virol       Date:  1968-03       Impact factor: 1.162

10.  Serological relationships between the neuraminidases in influenza viruses.

Authors:  C K Paniker
Journal:  J Gen Virol       Date:  1968-05       Impact factor: 3.891
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  3 in total

1.  [A new influenza subunit vaccine: reactogenicity and antigenicity in comparison to split and whole virus vaccines (author's transl)].

Authors:  C Kunz; H Hofmann; H Bachmayer; E Liehl; A Moritz
Journal:  Infection       Date:  1976       Impact factor: 3.553

2.  Differential effect of guanidine hydrochloride and heat on the haemagglutinin and neuraminidase of influenza viruses.

Authors:  T S David-West; G Belyavin
Journal:  Arch Gesamte Virusforsch       Date:  1973

3.  Degradation of influenza virus by non-ionic detergent.

Authors:  M J Corbel; C J Rondle; R G Bird
Journal:  J Hyg (Lond)       Date:  1970-03
  3 in total

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