Literature DB >> 4984762

In vitro susceptibility of Pseudomonas aeruginosa to carbenicillin and the combination of carbenicillin and gentamicin.

J P Phair, C Watanakunakorn, T Bannister.   

Abstract

One hundred and eleven strains of Pseudomonas aeruginosa isolated from clinical material were studied for susceptibility to carbenicillin. Of the strains, 80% were inhibited by 125 mug/ml or more. The combination of carbenicillin and gentamicin was shown to have inhibitory and bactericidal synergistic effect on 15 of 16 strains of P. aeruginosa tested. There was poor correlation between the single-disc sensitivity method and the tube dilution method.

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Year:  1969        PMID： 4984762      PMCID： PMC377973          DOI： 10.1128/am.18.3.303-306.1969

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  10 in total

1.  Single-disk antibiotic-sensitivity testing of staphylococci; an analysis of technique and results.

Authors:  A W BAUER; D M PERRY; W M KIRBY
Journal:  AMA Arch Intern Med       Date:  1959-08

2.  In vitro activity of carbenicillin against gram-negative bacilli.

Authors:  G P Bodey; L M Terrell
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

Review 3.  The use of combinations of antimicrobial drugs.

Authors:  E Jawetz
Journal:  Annu Rev Pharmacol       Date:  1968       Impact factor: 13.820

4.  Synergistic penicillin combinations for treatment of human urinary-tract infections.

Authors:  L D Sabath; C E McCall; N H Steigbigel; M Finland
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1966

5.  Carbenicillin: a new semisynthetic penicillin active against Pseudomonas pyocyanea.

Authors:  E T Knudsen; G N Rolinson; R Sutherland
Journal:  Br Med J       Date:  1967-07-08

6.  Induction of spheroplasts of Pseudomonas aeruginosa by carbenicillin.

Authors:  C Watanakunakorn; M Hamburger
Journal:  Appl Microbiol       Date:  1969-06

Review 7.  Methods and significance of in vitro testing of bacterial sensitivity to drugs.

Authors:  R G Petersdorf; J C Sherris
Journal:  Am J Med       Date:  1965-11       Impact factor: 4.965

8.  Staphylococcal spheroplasts and L colonies. IV. Antimicrobial susceptibility of stable methicillin-induced and lysostaphin-induced spheroplasts.

Authors:  C Watanakunakorn; L M Goldberg; J Carleton; M Hamburger
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1968

9.  COMPARISON OF SOME PROPERTIES OF PSEUDOMONAS AERUGINOSA ISOLATED FROM INFECTIONS IN PERSONS WITH AND WITHOUT CYSTIC FIBROSIS.

Authors:  R G DOGGETT; G M HARRISON; E S WALLIS
Journal:  J Bacteriol       Date:  1964-02       Impact factor: 3.490

10.  Carbenicillin: activity in vitro and absorption and excretion in normal young men.

Authors:  C B Smith; M Finland
Journal:  Appl Microbiol       Date:  1968-11
  10 in total
  20 in total

1.  In vitro synergism between carbenicillin and aminoglycosidic aminocyclitols against Acinetobacter calcoaceticus var. anitratus.

Authors:  R H Glew; R C Moellering; K R Buettner
Journal:  Antimicrob Agents Chemother       Date:  1977-06       Impact factor: 5.191

2.  Laboratory studies with a new broad-spectrum penicillin, pirbenicillin.

Authors:  J A Retsema; A R English; J E Lynch
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

3.  Comparison of cefazolin, a new cephalosporin antibiotic, with cephalothin.

Authors:  J P Phair; J Carleton; J S Tan
Journal:  Antimicrob Agents Chemother       Date:  1972-10       Impact factor: 5.191

4.  Susceptibility of Pseudomonas aeruginosa to carbenicillin.

Authors:  W H Traub; E A Raymond
Journal:  Appl Microbiol       Date:  1970-10

5.  Synergistic activity of carbenicillin and gentamicin in experimental Pseudomonas bacteremia in neutropenic rats.

Authors:  R E Scott; H G Robson
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191

6.  Activity of newer aminoglycosides and carbenicillin, alone and in combination, against gentamicin-resistant Pseudomonas aeruginosa.

Authors:  M I Marks; S Hammerberg; G Greenstone; B Silver
Journal:  Antimicrob Agents Chemother       Date:  1976-09       Impact factor: 5.191

7.  Susceptibility of Pseudomonas aeruginosa to tobramycin or gentamicin alone and combined with carbenicillin.

Authors:  E L Anderson; P K Gramling; P R Vestal; W E Farrar
Journal:  Antimicrob Agents Chemother       Date:  1975-09       Impact factor: 5.191

8.  Virulence in rats of gentamicin-carbenicillin-resistant Pseudomonas.

Authors:  J M Slepack; T Korfhagen; J C Loper; J S Tan; J P Phair
Journal:  Antimicrob Agents Chemother       Date:  1975-10       Impact factor: 5.191

9.  In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens.

Authors:  S M Pogwizd; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1976-12       Impact factor: 5.191

10.  Carbenicillin and gentamicin in the treatment of Pseudomonas aeruginosa infection.

Authors:  K Yuce; C E Van Rooyen
Journal:  Can Med Assoc J       Date:  1971-11       Impact factor: 8.262
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