Literature DB >> 4983672

Penicillin as epileptogenic agent: its effect on an isolated neuron.

G F Ayala, S Lin, C Vasconetto.   

Abstract

Penicillin induces partial depolarization and increased excitability of the neuronal membrane of crayfish stretch receptor. Such effects suggest that the epileptic focus created by the topical application of penicillin to the mammalian cerebral cortex may result from the lowering of the threshold for impluse initiation by excitatory synaptic action within the neuron population.

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Year:  1970        PMID: 4983672     DOI: 10.1126/science.167.3922.1257

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

1.  Effects of a focal penicillin lesion on responses of rabbit cortical neurones to putative neurotransmitters.

Authors:  G Clarke; R G Hill
Journal:  Br J Pharmacol       Date:  1972-03       Impact factor: 8.739

2.  A comparative study of some convulsant substances as gamma-aminobutyric acid antagonists in the feline cerebral cortex.

Authors:  R G Hill; M A Simmonds; D W Straughan
Journal:  Br J Pharmacol       Date:  1973-09       Impact factor: 8.739

3.  Ultrastructural and biochemical studies on ouabain-induced oedematous brain.

Authors:  R Tanaka; K Tanimura; K Ueki
Journal:  Acta Neuropathol       Date:  1977-02-28       Impact factor: 17.088

  3 in total

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