| Literature DB >> 498139 |
J B Adams, T Pewnim, D P Chandra, L Archibald, M S Foo.
Abstract
Estrogen sulfotransferase (EC 2.8.2.4) activity and estrogen receptor levels were measured in 32 human primary breast cancer cytosol preparations. Two types of tumors were identified: type 1, in which estrogen sulfotransferase levels were low (less than 40 pmol 17 beta-estradiol 3-sulfate formed per mg protein per 2 hr) and were independent of [35S]adenosine 3'-phosphate 5'-phosphosulfate production from [35S]sulfate and adenosine triphosphate, and type 2, in which estrogen sulfotransferase levels ranged from 50 to 200 pmol 17 beta-estradiol 3-sulfate per mg protein per 2 hr and were correlated with [35S]adenosine 3'-phosphate 5'-phosphosulfate formation (r = 0.70; p less than 0.005). In type 1 tumors, 11 of 16 were estrogen receptor negative; in type 2 tumors, 2 of 16 were receptor negative. Estrogen sulfotransferase levels in receptor-negative tumors were significantly lower than the levels in receptor-positive tumors (p = 0.025).Entities:
Keywords: Biology; Breast Cancer; Cancer; Clinical Research; Correlation Studies; Diseases; Endocrine System; Estrogens--analysis; Hormone Receptors--analysis; Hormones; In Vitro; Membrane Proteins; Neoplasms; Physiology; Research Methodology; Statistical Studies; Studies
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Year: 1979 PMID： 498139
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701