Literature DB >> 4981033

Carbonic acid production and the role of carbonic anhydrase in decarboxylation in brain.

J W Severinghaus, F N Hamilton, S Cotev.   

Abstract

Sudden oxygenation of a thin film of rat brain homogenate, suspended between the surface of a glass pH-sensitive electrode and a gas-permeable membrane, is accompanied by a fall in pH, which is greater when carbonic anhydrase is inhibited. The result suggests that oxidative decarboxylation yields carbonic acid (HCO(3)- and H(+)), which dissociates to form molecular carbon dioxide. Brain carbonic anhydrase facilitates the formation of carbon dioxide from the decarboxylation products.

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Year:  1969        PMID： 4981033      PMCID： PMC1184955          DOI： 10.1042/bj1140703

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  CEREBRAL TISSUE RESPIRATION: EFFECT OF ACETAZOLAMIDE AND CALCIUM IONS.

Authors:  A THANGAMANI
Journal:  Biochem Pharmacol       Date:  1965-01-01       Impact factor: 5.858

2.  Distribution of carbonic anhydrase in human brain.

Authors:  T NISHIMURA; H TANIMUKAI; K NISHINUMA
Journal:  J Neurochem       Date:  1963-04       Impact factor: 5.372

3.  The immediate product of braintissue decarboxylations.

Authors:  R M NATOUR; R F PALMER
Journal:  Biochem J       Date:  1962-10       Impact factor: 3.857

4.  A cytochemical study of the localization of carbonic anhydrase in the nervous system.

Authors:  E GIACOBINI
Journal:  J Neurochem       Date:  1962 Mar-Apr       Impact factor: 5.372

5.  Intracellular distribution of carbonic anhydrase.

Authors:  R KARLER; D M WOODBURY
Journal:  Biochem J       Date:  1960-06       Impact factor: 3.857

6.  The effect of carbonic anhydrase on the action of yeast carboxylase.

Authors:  E J CONWAY; E O'MALLEY
Journal:  Biochem J       Date:  1953-04       Impact factor: 3.857

Review 7.  Carbonic anhydrase: chemistry, physiology, and inhibition.

Authors:  T H Maren
Journal:  Physiol Rev       Date:  1967-10       Impact factor: 37.312

8.  Carbonic anhydrase as a tool in studying the mechanism of reactions involving H(2)CO(3), CO(2) or HCO(3)'.

Authors:  H A Krebs; F J Roughton
Journal:  Biochem J       Date:  1948       Impact factor: 3.857
  8 in total
  3 in total

1.  The isoenzymes of carbonic anhydrase: tissue, subcellular distribution and functional significance, with particular reference to the intestinal tract.

Authors:  M J Carter; D S Parsons
Journal:  J Physiol       Date:  1971-05       Impact factor: 5.182

2.  Correlation of angiographic circulation time and cerebrovascular reserve by acetazolamide-challenged single photon emission CT.

Authors:  Shiro Yamamoto; Manabu Watanabe; Toshihiko Uematsu; Kenichiro Takasawa; Masaru Nukata; Naokazu Kinoshita
Journal:  AJNR Am J Neuroradiol       Date:  2004-02       Impact factor: 3.825

3.  Transient response of muscle and nonbrain tissue to adjustments in O2 and CO2 balance.

Authors:  A Bidani; R W Flumerfelt
Journal:  Ann Biomed Eng       Date:  1981       Impact factor: 3.934
  3 in total

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