Literature DB >> 498069

In vitro cytokinetic response of human colon cancer cells to cis-dichlorodiammineplatinum(II).

J P Bergerat, B Barlogie, W Göhde, D A Johnston, B Drewinko.   

Abstract

The cytokinetic response of a human colon carcinoma cell line to cis-dichlorodiammineplatinum(II) was investigated using flow cytometry of DNA content, autoradiography after pulse and continuous tritiated thymidine exposure, and mitotic accumulation after continuous Colcemid treatment. With increasing concentration and exposure time, cis-dichlorodiammineplatinum(II) delayed and then blocked cycle traverse in S and G2 phases. After prolonged treatment with high concentrations of cis-dichlorodiammineplatinum(II), an additional block in G1 or at the G1-S boundary was established. Irreversibility of cell cycle distribution changes after prolonged observation periods suggests cell death in G2, S, and G1 compartments.

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Year:  1979        PMID： 498069

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  10 in total

1.  Antiproliferation and apoptosis induction of paeonol in HepG2 cells.

Authors:  Shu-Ping Xu; Guo-Ping Sun; Yu-Xian Shen; Wei Wei; Wan-Ren Peng; Hua Wang
Journal:  World J Gastroenterol       Date:  2007-01-14       Impact factor: 5.742

2.  Cytokinetic effects of cisplatin on diverse human head and neck carcinomas in vitro: dependence on the tumor sensitivity to cisplatin.

Authors:  M C Jäckel; R Tausch-Treml; P Köpf-Maier
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

3.  Influence of cis-dichlorodiamineplatinum on glioma cell morphology and cell cycle kinetics in tissue culture.

Authors:  V Mares; P A Giordano; G Mazzini; V Lisá; C Pellicciari; E Scherini; G Bottiroli; J Drobnik
Journal:  Histochem J       Date:  1987-04

Review 4.  Antitumor activity of platinum complexes.

Authors:  J Drobník
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

5.  Influence of cisplatin on cell-cycle progression in xenografted human head and neck carcinomas.

Authors:  M Jäckel; P Köpf-Maier
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

6.  Prolongation of G1 phase in cultured glioma cells by cis-dichlorodiammineplatinum (II) (CDDP): analysis using bromodeoxyuridine (BrdU)-Hoechst technique.

Authors:  T Morimura
Journal:  J Neurooncol       Date:  1989-05       Impact factor: 4.130

7.  Induction of cell arrest at G1/S and in G2 after treatment of Ehrlich ascites tumor cells with metallocene dichlorides and cis-platinum in vitro.

Authors:  P Köpf-Maier; W Wagner; E Liss
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

8.  Pharmacokinetics of cisplatin during hyperthermic intraperitoneal treatment of peritoneal carcinomatosis.

Authors:  P H Cashin; H Ehrsson; I Wallin; P Nygren; H Mahteme
Journal:  Eur J Clin Pharmacol       Date:  2012-09-16       Impact factor: 2.953

9.  The role of apoptosis in cell killing by cisplatin: a flow cytometric study.

Authors:  M G Ormerod; R M Orr; J H Peacock
Journal:  Br J Cancer       Date:  1994-01       Impact factor: 7.640

10.  Kinetic analysis of combination effect of navelbine (KW-2307) with cisplatin against human lung adenocarcinoma PC-12 cells in culture.

Authors:  K Gomi; H Ohno; K Nomura; M Okabe; K Kobayashi; H Niitani
Journal:  Jpn J Cancer Res       Date:  1992-05
  10 in total

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