Literature DB >> 4979177

Ultraviolet light alteration of cellular deoxyribonucleic acid in vivo.

E M Tan, R B Stoughton.   

Abstract

DNA after irradiation with ultraviolet light was immunogenic in rabbits and elicited serum antibodies reacting specifically with UV-irradiated DNA. The serological reactions were demonstrated by immunodiffusion, complement fixation, and immunofluorescence. By immunofluorescence, antisera reacted with cell nuclei of irradiated tissue sections but not with unirradiated tissue. This method was employed to show the presence of UV lesions in tissues of mice exposed to UV light. UV lesions in DNA were present in nuclei of epidermal cells, and in heavily irradiated animals they were also detected in the corium immediately below the epidermis. The method is useful not only for directly demonstrating UV lesions of DNA but also for localizing such lesions in tissues.

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Year:  1969        PMID： 4979177      PMCID： PMC223656          DOI： 10.1073/pnas.62.3.708

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  EVIDENCE FOR REPAIR OF ULTRA-VIOLET DAMAGED DEOXYRIBONUCLEIC ACID IN CULTURED MAMMALIAN CELLS.

Authors:  R E RASMUSSEN; R B PAINTER
Journal:  Nature       Date:  1964-09-26       Impact factor: 49.962

2.  Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition.

Authors:  E WASSERMAN; L LEVINE
Journal:  J Immunol       Date:  1961-09       Impact factor: 5.422

3.  SPECIFIC ANTIBODIES TO THERMALLY DENATURED DEOXYRIBONUCLEIC ACID OF PHAGE T4.

Authors:  L Levine; W T Murakami; H V Vunakis; L Grossman
Journal:  Proc Natl Acad Sci U S A       Date:  1960-08       Impact factor: 11.205

Review 4.  The photochemistry, photobiology, and repair of polynucleotides.

Authors:  R B Setlow
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1968

5.  Radiation stimulated incorporation of thymidine into the DNA of human lymphocytes.

Authors:  R G Evans; A Norman
Journal:  Nature       Date:  1968-02-03       Impact factor: 49.962

Review 6.  Nucleic acids as antigens.

Authors:  O J Plescia; W Braun
Journal:  Adv Immunol       Date:  1967       Impact factor: 3.543

7.  Relationship of nuclear staining patterns with precipitating antibodies in systemic lupus erythematosus.

Authors:  E M Tan
Journal:  J Lab Clin Med       Date:  1967-11

8.  Evidence for repair replication of HeLa cell DNA damaged by ultraviolet light.

Authors:  J R Cleaver; R B Painter
Journal:  Biochim Biophys Acta       Date:  1968-07-23

9.  Fluorescent antibody staining. 3. Preparation of fluorescein-isothiocyanate-labeled antibodies.

Authors:  B T Wood; S H Thompson; G Goldstein
Journal:  J Immunol       Date:  1965-08       Impact factor: 5.422

10.  Antibodies to photoproducts of deoxyribonucleic acids irradiated with ultraviolet light.

Authors:  L Levine; E Seaman; E Hammerschlag; H Van Vunakis
Journal:  Science       Date:  1966-09-30       Impact factor: 47.728
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  10 in total

1.  Ultraviolet Light-induced Formation of Pisatin and Phenylalanine Ammonia Lyase.

Authors:  L A Hadwiger; M E Schwochau
Journal:  Plant Physiol       Date:  1971-04       Impact factor: 8.340

2.  Light-induced skin lesions in lupus erythematosus: photobiological studies.

Authors:  H van Weelden; P J Velthuis; H Baart de la Faille
Journal:  Arch Dermatol Res       Date:  1989       Impact factor: 3.017

3.  Immunologic implications of PUVA therapy in psoriasis vulgaris.

Authors:  R H Cormane; F Hamerlinck; A H Siddiqui
Journal:  Arch Dermatol Res       Date:  1979-07-30       Impact factor: 3.017

4.  Induction of antinuclear antibodies by ultraviolet irradiation.

Authors:  J H Veen; C J Lucas
Journal:  Ann Rheum Dis       Date:  1970-09       Impact factor: 19.103

5.  Recurrence of pterygium after excision.

Authors:  R M Youngson
Journal:  Br J Ophthalmol       Date:  1972-02       Impact factor: 4.638

6.  Contribution of modern immunological concepts to an understanding of diseases of the skin.

Authors:  J L Turk
Journal:  Br Med J       Date:  1970-08-15

7.  Pathogenesis of lupus dermatoses in autoimmune mice. IV. Association between cutaneous immunoglobulin deposition and anti-single-stranded DNA antibodies in sera.

Authors:  F Furukawa; A Kohno; G Ohshio; K Suzuki; Y Hamashima
Journal:  Arch Dermatol Res       Date:  1985       Impact factor: 3.017

8.  Activation of IL-6 production by UV irradiation of blood mononuclear cells from patients with systemic lupus erythematosus.

Authors:  B K Pelton; W Hylton; A M Denman
Journal:  Clin Exp Immunol       Date:  1992-08       Impact factor: 4.330

9.  Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation.

Authors:  T D Golan; K B Elkon; A E Gharavi; J G Krueger
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

10.  Experimental renal disease induced by DNA-anti-DNA immune complexes.

Authors:  P G Natali; E M Tan
Journal:  J Clin Invest       Date:  1972-02       Impact factor: 14.808
  10 in total

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