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Literature DB >> 4978743

A template-selective inhibitor of in vitro transcription.

Abstract

A macromolecular factor, TF1, has been isolated from bacteriophage SP01-infected B. subtilis. TF1 selectively inhibits in vitro transcription of SP01 and related viral DNA. Evidence is presented regarding these properties of the repressor-like TF1: (1) template and conformational specificity; (2) interaction with DNA rather than RNA polymerase; (3) trypsin sensitivity; (4) reversibility of action; and (5) ability to block initiation, but not propagation, of RNA synthesis.

Entities: Gene Species

Mesh：

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Year: 1969 PMID： 4978743 PMCID： PMC277828 DOI： 10.1073/pnas.62.2.514

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. Genetic regulatory mechanisms in the synthesis of proteins.

Authors: F JACOB; J MONOD
Journal: J Mol Biol Date: 1961-06 Impact factor: 5.469

2. Interaction of rifamycin with bacterial RNA polymerase.

Authors: W Wehrli; F Knüsel; K Schmid; M Staehelin
Journal: Proc Natl Acad Sci U S A Date: 1968-10 Impact factor: 11.205

3. The lac operator is DNA.

Authors: W Gilbert; B Müller-Hill
Journal: Proc Natl Acad Sci U S A Date: 1967-12 Impact factor: 11.205

4. Mode of action of rafamycin on the RNA polymerase reaction.

Authors: A Sippel; G Hartmann
Journal: Biochim Biophys Acta Date: 1968-03-18

5. Transcription during bacteriophage T4 development: synthesis and relative stability of early and late RNA.

Authors: A Bolle; R H Epstein; W Salser; E P Geiduschek
Journal: J Mol Biol Date: 1968-02-14 Impact factor: 5.469

6. Repression of early messenger transcription in the development of a bacteriophage.

Authors: L P Gage; E P Geiduschek
Journal: J Mol Biol Date: 1967-12-14 Impact factor: 5.469

7. On the transcription of the tryptophan operon in Escherichia coli. 3. Multicistronic messenger RNA and polarity for transcription.

Authors: F Imamoto; N Morikawa; K Sato
Journal: J Mol Biol Date: 1965-08 Impact factor: 5.469

8. In vitro repression of phage lambda DNA transcription by a partially purified repressor from lysogenic cells.

Authors: H Echols; L Pilarski; P Y Xcheng
Journal: Proc Natl Acad Sci U S A Date: 1968-03 Impact factor: 11.205

9. The operators controlled by the lambda phage repressor.

Authors: M Ptashne; N Hopkins
Journal: Proc Natl Acad Sci U S A Date: 1968-08 Impact factor: 11.205

10. Deoxyribonucleic acid replication and expression of early and late bacteriophage functions in Bacillus subtilis.

Authors: J J Pène; J Marmur
Journal: J Virol Date: 1967-02 Impact factor: 5.103

10 in total

1. Construction and properties of a temperature-sensitive mutation in the gene for the bacteriophage SPO1 DNA-binding protein TF1.

Authors: M H Sayre; E P Geiduschek
Journal: J Bacteriol Date: 1990-08 Impact factor: 3.490

2. Determinants of affinity and mode of DNA binding at the carboxy terminus of the bacteriophage SPO1-encoded type II DNA-binding protein, TF1.

Authors: L Andera; E P Geiduschek
Journal: J Bacteriol Date: 1994-03 Impact factor: 3.490

Review 3. Bacteriophages of Bacillus subtilis.

Authors: H E Hemphill; H R Whiteley
Journal: Bacteriol Rev Date: 1975-09

7. Bacteriophage SPO1 DNA- and RNA-directed protein synthesis in vitro: the effect of TF1, a template-selective transcription inhibitor.

Authors: D A Shub; G G Johnson
Journal: Mol Gen Genet Date: 1975