| Literature DB >> 497816 |
S H Dorfman, J M Fry, D H Silberberg.
Abstract
Exposure of neonatal rat cerebellum cultures to antiserum to whole spinal cord or galactocerebroside inhibited myelin formation regardless of whether guinea pig serum was added fresh or after heating to 56 degrees C for 1 h in order to achieve complete removal of hemolytic complement activity. Myelination followed removal of antisera from the culture media. This suggests that the inhibition of primary myelination by anti-CNS tissue antiserum occurs through some mechanism other than as the result of a cytotoxic reaction against oligodendrocytes mediated via the complement system.Entities:
Mesh:
Substances:
Year: 1979 PMID: 497816 DOI: 10.1016/0006-8993(79)90921-1
Source DB: PubMed Journal: Brain Res ISSN: 0006-8993 Impact factor: 3.252