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Literature DB >> 4973219

The potentiation of rat uterine inhibitory responses to noradrenaline by theophylline and nitroglycerine.

Abstract

1. Dose response curves for noradrenaline were determined before, during and after pretreatment with a variety of agents. The inhibitory response to noradrenaline on the isolated rat uterus was measured according to its ability to inhibit an acetylcholine induced contraction.2. Theophylline, an agent that inhibits phosphodiesterase and increases cyclic AMP levels in the rat, potentiated the response to noradrenaline.3. Pretreatment with cocaine had no significant effect on the potentiation of the noradrenaline response by theophylline.4. Theophylline potentiated the inhibitory response to nitroglycerine.5. Pretreatment with nitroglycerine also potentiated the inhibitory response to noradrenaline.6. Theophylline appears to produce a potentiation of the inhibitory effect of noradrenaline on the rat uterus by means of a non-specific mechanism.

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Year: 1968 PMID： 4973219 PMCID： PMC1703519 DOI： 10.1111/j.1476-5381.1968.tb08489.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

13 in total

10. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

Authors: R W BUTCHER; E W SUTHERLAND
Journal: J Biol Chem Date: 1962-04 Impact factor: 5.157

6 in total

4. Comparative effects of glyceryl trinitrate on venous and arterial smooth muscle in vitro; relevance to antianginal activity.

Authors: J E Mackenzie; J R Parratt
Journal: Br J Pharmacol Date: 1977-05 Impact factor: 8.739

5. Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips.

Authors: S Kalsner
Journal: Br J Pharmacol Date: 1971-10 Impact factor: 8.739

6. The effects of (+)- and (-)-propranolol on 3H-transmitter efflux in guinea-pig atria and the presynaptic beta-adrenoceptor hypothesis.

Authors: S Kalsner
Journal: Br J Pharmacol Date: 1980-11 Impact factor: 8.739

6 in total

The potentiation of rat uterine inhibitory responses to noradrenaline by theophylline and nitroglycerine.

1. ALTERATIONS OF ADRENERGIC RESPONSES BY N-ISOPROPYLMETHOXAMINE.

2. THE ADRENERGIC RECEPTIVE MECHANISM OF THE RAT UTERUS.

3. The potentiation of cardiac inotropic responses to norepinephrine by theophylline.

4. The action of histamine and 5-hydroxytryptamine on isolated mammalian atria.

Review 5. Hormonal control of carbohydrate and lipid metabolism and drug induced alterations.

6. Investigation into the mode of action of histamine on the isolated rabbit heart.

Review 7. Adenyl cyclase as an adrenergic receptor.

Review 8. Second symposium on catecholamines. Physiological interrelationships. Introductory remarks.

9. Blockade of the biochemical correlates of contraction and relaxation in uterine and intestinal smooth muscle.

10. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

1. Apparent irrelevance of cyclic nucleotides to the relaxation of tracheal smooth muscle induced by theophylline.

2. [The influence of drugs on perfusion pressure and contractility of the human uterus. I. (author's transl)].

3. The nature of the positive inotropic response of the isolated frog heart to theophylline and to iminazole.

4. Comparative effects of glyceryl trinitrate on venous and arterial smooth muscle in vitro; relevance to antianginal activity.

5. Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips.

6. The effects of (+)- and (-)-propranolol on 3H-transmitter efflux in guinea-pig atria and the presynaptic beta-adrenoceptor hypothesis.