Literature DB >> 497072

A screening test for the malignant hyperpyrexia phenotype using suxamethonium-induced contracture of muscle treated with caffeine and its inhibition by dantrolene.

P J Halsall, F R Ellis.   

Abstract

Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro. The contracture was significantly greater (P less than 0.001) with MHS muscle compared with muscle from normal subjects. This reaction is now used as an additional screening test for the MHS phenotype. The contracture was prevented by pretreatment with dantrolene.

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Year:  1979        PMID： 497072     DOI： 10.1093/bja/51.8.753

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN： 0007-0912            Impact factor:   9.166


  4 in total

Review 1.  Dantrolene.

Authors:  B A Britt
Journal:  Can Anaesth Soc J       Date:  1984-01

Review 2.  Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.

Authors:  A Ward; M O Chaffman; E M Sorkin
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

3.  Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study.

Authors:  Werner Klingler; Sebastian Heiderich; Thierry Girard; Elvira Gravino; James Ja Heffron; Stephan Johannsen; Karin Jurkat-Rott; Henrik Rüffert; Frank Schuster; Marc Snoeck; Vincenzo Sorrentino; Vincenzo Tegazzin; Frank Lehmann-Horn
Journal:  Orphanet J Rare Dis       Date:  2014-01-16       Impact factor: 4.123

4.  Clinical, morphological and genetic characterization of Brody disease: an international study of 40 patients.

Authors:  Joery P Molenaar; Jamie I Verhoeven; Richard J Rodenburg; Erik J Kamsteeg; Corrie E Erasmus; Savine Vicart; Anthony Behin; Guillaume Bassez; Armelle Magot; Yann Péréon; Barbara W Brandom; Valeria Guglielmi; Gaetano Vattemi; Frédéric Chevessier; Jean Mathieu; Jérôme Franques; Karen Suetterlin; Michael G Hanna; Lucie Guyant-Marechal; Marc M Snoeck; Mark E Roberts; Thierry Kuntzer; Roberto Fernandez-Torron; Amaia Martínez-Arroyo; Juergen Seeger; Benno Kusters; Susan Treves; Baziel G van Engelen; Bruno Eymard; Nicol C Voermans; Damien Sternberg
Journal:  Brain       Date:  2020-02-01       Impact factor: 13.501
  4 in total

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