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Literature DB >> 4960159

Mode of action of antibiotic U-20,661.

Abstract

Antibiotic U-20,661 was shown to inhibit predominantly deoxyribonucleic acid (DNA)-directed ribonucleic acid (RNA) synthesis by binding to the double-stranded DNA template. Specific binding to DNA was verified by difference spectroscopy, reversal of the RNA polymerase inhibitory effect by increasing concentrations of DNA template, and by moderately increasing the melting temperature of double-stranded DNA in the presence of the antibiotic. The RNA polymerase reaction primed with synthetic poly dAT was inhibited considerably, but not completely even with high concentrations of antibiotic. Thus, the agent might bind to adenine or thymidine or both bases in the double-stranded DNA helix.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1967 PMID： 4960159 PMCID： PMC314969 DOI： 10.1128/jb.93.1.65-70.1967

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

12 in total

1. THE MECHANISM OF ACTION OF CARBOXYDISMUTASE.

Authors: P W TROWN; B R RABIN
Journal: Proc Natl Acad Sci U S A Date: 1964-07 Impact factor: 11.205

2. ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI.

Authors: C C RICHARDSON; C L SCHILDKRAUT; H V APOSHIAN; A KORNBERG
Journal: J Biol Chem Date: 1964-01 Impact factor: 5.157

9. Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chormomycin, mithramycin, and olivomycin).

Authors: W Kersten; H Kersten; W Szybalski
Journal: Biochemistry Date: 1966-01 Impact factor: 3.162

10. The formation apurinic acid from the desoxyribonucleic acid of calf thymus.

Authors: C TAMM; M E HODES; E CHARGAFF
Journal: J Biol Chem Date: 1952-03 Impact factor: 5.486

6 in total

1. Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.

Authors: Sonia Gullón; Carlos Olano; Mohamed S Abdelfattah; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal: Appl Environ Microbiol Date: 2006-06 Impact factor: 4.792

Mode of action of antibiotic U-20,661.

1. THE MECHANISM OF ACTION OF CARBOXYDISMUTASE.

2. ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI.

3. Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli.

4. Characteristics and stabilization of DNAase-sensitive protein synthesis in E. coli extracts.

5. DNA polymerase and deoxyribonucleotide kinase activities in cells infected with vaccinia virus.

6. Protein measurement with the Folin phenol reagent.

7. Differential interaction of nogalamycin with DNA of varying base composition.

Review 8. Actinomycin and nucleic acid function.

9. Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chormomycin, mithramycin, and olivomycin).

10. The formation apurinic acid from the desoxyribonucleic acid of calf thymus.

1. Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.

2. Mode of action of albocycline, an inhibitor of nicotinate biosynthesis.

3. Mode of action of antibiotic U-24,544.

4. Comparative studies with three antibiotics binding to deoxyribonucleic acid.

5. Tirandamycin: inhibition of ribonucleic Acid polymerase.

6. Mode of action of melinacidin, an inhibitor of nicotinic acid biosynthesis.