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Literature DB >> 4959011

Occurrence and properties of a macroglobulin dimer in some hyperglobulinemic sera.

Abstract

A 22S human gammaM-globulin component has been subjected to various study. It appears to be a dimer of 19S proteins and can undergo reversible molecular transitions which are both pH and temperature dependent. The 22S material regenerated from its 8S subunits no longer undergo similar transformations. Efforts to demonstrate that the 22S material was an antigen-antibody complex of 19S molecules were unsuccessful. Complex precipitin reactions in gels are given by macroglobulins containing this component with antibody to L chains.

Entities: Disease Mutation Species

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Year: 1966 PMID： 4959011 PMCID： PMC2138266 DOI： 10.1084/jem.124.5.819

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

8. A comparison of the native and monomer forms of macroglobulin from pathological human serum with particular reference to electrophoretic mobility differences.

Authors: E I McDougall; H F Deutsch
Journal: Biochem J Date: 1964-01 Impact factor: 3.857

Occurrence and properties of a macroglobulin dimer in some hyperglobulinemic sera.

1. STUDIES WITH RHESUS MONKEYS ANTISERA TO HUMAN GAMMA-M-GLOBULINS (GAMMA-M).

2. Anti-gamma-globulin factors in human sera revealed by enzymatic splitting of anti-Rh antibodies.

3. An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.

4. Ultracentrifugal characteristics and carbohydrate content of macromolecular gamma-globulins.

5. Dissociation of human serum macroglobulins.

6. Human serum macroglobulins and dissociation units. I. Physicochemical properties.

7. A crystalline macroglobulin from human serum.

8. A comparison of the native and monomer forms of macroglobulin from pathological human serum with particular reference to electrophoretic mobility differences.

9. Macroglobulin rheumatoid factors directed toward buried antigenic sites of human gamma-globulins.

10. PROPERTIES OF VARIOUS ANTI-GAMMA-GLOBULIN FACTORS IN HUMAN SERA.

1. [On the conformation of macroglobulins in Waldenstöm's disease. 3. On the kinetics of mercaptoethanol denaturation].

2. Rheumatoid factors reacting with autologous native gamma-G-globulin and joint fluid gamma-G aggregates.

3. Ultrastructure of papain and pepsin digestion fragments of human IgM globulins.

4. The subunits in rabbit anti-Forssman IgM antibody.