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Literature DB >> 4956041

Site of action of certain antibacterial heterocyclic quaternary ammonium compounds.

Abstract

The site of action of related mono- and bis-quinaldinium compounds was investigated in Staphylococcus aureus and Bacillus megaterium. The effects of these compounds on cell morphology and on protoplast formation and fragility were studied, and the distribution of C(14)-labeled quinaldinium compound in cell fractions was measured. The latter studies showed that a major part of the quaternary compound penetrates the cell, leaving a very small quantity associated with the cell wall. Similar antibacterial effects were seen with both the mono- and bis-quinaldinium compounds studied, and these effects were comparable with antibacterial properties of known cationic surface-active antibacterial agents.

Entities: Chemical Species

Mesh：

Substances：

Year: 1965 PMID： 4956041 PMCID： PMC1058378 DOI： 10.1128/am.13.6.956-966.1965

Source DB: PubMed Journal: Appl Microbiol ISSN： 0003-6919

11 in total

1. The antibacterial activity of new derivatives of 4-aminoquinoline and 4-aminoquinaldine.

Authors: D CALDWELL; W A COX; P F D'ARCY; L R ROWE
Journal: J Pharm Pharmacol Date: 1961-09 Impact factor: 3.765

2. Some observations on the fine structure of Staphylococcus aureus.

Authors: A SUGANUMA
Journal: J Infect Dis Date: 1962 Jul-Aug Impact factor: 5.226

3. Lysis of protoplasts of Micrococcus lysodeikticus by ionic detergents.

Authors: A R GILBY; A V FEW
Journal: J Gen Microbiol Date: 1960-08

4. Effect of disinfectants and of surface active agents on bacterial protoplasts.

Authors: J TOMCSIK
Journal: Proc Soc Exp Biol Med Date: 1955-07

5. A mechanical cell disintegrator.

Authors: P M NOSSAL
Journal: Aust J Exp Biol Med Sci Date: 1953-12

6. An electron-microscope study of the action of cetyl-trimethyl-ammonium bromide on Staphylococcus aureus.

Authors: I M DAWSON; I LOMINSKI; H STERN
Journal: J Pathol Bacteriol Date: 1953-10

7. Electron microscopy of bacteria treated with cetyltrimethylammonium bromide.

Authors: M R J SALTON; R W HORNE; V E COSSLETT
Journal: J Gen Microbiol Date: 1951-05

8. The adsorption of cetyltrimethylammonium bromide by bacteria, its action in releasing cellular constituents and its bactericidal effects.

Authors: M R J SALTON
Journal: J Gen Microbiol Date: 1951-05

Site of action of certain antibacterial heterocyclic quaternary ammonium compounds.

1. The antibacterial activity of new derivatives of 4-aminoquinoline and 4-aminoquinaldine.

2. Some observations on the fine structure of Staphylococcus aureus.

3. Lysis of protoplasts of Micrococcus lysodeikticus by ionic detergents.

4. Effect of disinfectants and of surface active agents on bacterial protoplasts.

5. A mechanical cell disintegrator.

6. An electron-microscope study of the action of cetyl-trimethyl-ammonium bromide on Staphylococcus aureus.

7. Electron microscopy of bacteria treated with cetyltrimethylammonium bromide.

8. The adsorption of cetyltrimethylammonium bromide by bacteria, its action in releasing cellular constituents and its bactericidal effects.

9. The isolation of alpha epsilon-Diaminopimelic acid from Corynebacterium diphtheriae and Mycobacterium tuberculosis.

10. Salts of decamethylene-bis-4-aminoquinaldinium (dequadin); a new antimicrobial agent.

1. Changes in Escherichia coli associated with acquired tolerance for quaternary ammonium compounds.

2. Antimicrobial actions of hexachlorophene: cytological manifestations.

3. Mode of action of the antibacterial compound dequalinium acetate.

Review 4. Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review.