Classification of neuromuscular disorders.

Anew type of classification of neuromuscular diseases is presented. It is based on etiology; when this is not possible, on pathogenesis; if neither is possible, on distinctive features, biochemical greater than morphologic greater than clinical-genetic ones. The initial categorization designates which cell type, lower motor neuron or myofiber, is considered responsible for the major abnormality. This classification is designed to promote understanding of the pathogenesis and etiology of neuromuscular diseases in general and be applicable to a particular patient when the diagnostic studies are completed. It is not arranged as an approach to the initial differential diagnosis of a given patient.