Literature DB >> 494365

Pituitary metabolism of 5alpha-androstane-3beta-17beta-diol: intense and rapid conversion into 5alpha-androstane-3beta,6alpha,17beta-triol and 5alpha-androstane-3beta,7alpha, 17beta-triol.

J M Guiraud, R Morfin, B Ducouret, S Samperez, P Jouan.   

Abstract

In the male rat pituitary, 5alpha-androstane-3beta, 17beta-diol (3beta-diol) is extensively metabolized into polar steroids. They were identified as 5alpha-androstane-3beta, 6alpha-17beta-triol (6alpha-triol) and 5alpha-androstane-3beta, 7alpha, 17beta-triol (7alpha-triol). 6-alpha-Triol represents 53% and 7alpha-Triol 28% of the total 3beta-diol metabolites. The remaining percentage is related to 6beta and 7beta isomers. The biological role of triols is still unknown.

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Year:  1979        PMID: 494365     DOI: 10.1016/0039-128x(79)90076-x

Source DB:  PubMed          Journal:  Steroids        ISSN: 0039-128X            Impact factor:   2.668


  3 in total

1.  Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes.

Authors:  Y Akwa; R F Morfin; P Robel; E E Baulieu
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

Review 2.  Estrogen receptor β and Liver X receptor β: biology and therapeutic potential in CNS diseases.

Authors:  M Warner; J-A Gustafsson
Journal:  Mol Psychiatry       Date:  2014-03-25       Impact factor: 15.992

3.  Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.

Authors:  C Corpéchot; P Robel; M Axelson; J Sjövall; E E Baulieu
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

  3 in total

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