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Literature DB >> 493992

Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor.

Abstract

Micropipettes containing 2 to 50 biological units of beta growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.

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Substances：
Nerve Growth Factors

Year: 1979 PMID： 493992 DOI： 10.1126/science.493992

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

79 in total

Review 1. Neurotrophins: roles in neuronal development and function.

Authors: E J Huang; L F Reichardt
Journal: Annu Rev Neurosci Date: 2001 Impact factor: 12.449

2. A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation.

Authors: Patrick S McQuillen; Michael F DeFreitas; Gabriel Zada; Carla J Shatz
Journal: J Neurosci Date: 2002-05-01 Impact factor: 6.167

3. Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone.

Authors: G Szebenyi; E W Dent; J L Callaway; C Seys; H Lueth; K Kalil
Journal: J Neurosci Date: 2001-06-01 Impact factor: 6.167

4. Local neurotrophin effects on central trigeminal axon growth patterns.

Authors: P Hande Ozdinler; Emel Ulupinar; Reha S Erzurumlu
Journal: Brain Res Dev Brain Res Date: 2004-07-19

5. Development of resting membrane potentials in differentiating murine neuroblastoma cells (N1E-115) evaluated by flow cytometry.

Authors: W S Kisaalita; J M Bowen
Journal: Cytotechnology Date: 1997-09 Impact factor: 2.058

Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor.

Review 1. Neurotrophins: roles in neuronal development and function.

2. A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation.

3. Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone.

4. Local neurotrophin effects on central trigeminal axon growth patterns.

5. Development of resting membrane potentials in differentiating murine neuroblastoma cells (N1E-115) evaluated by flow cytometry.

Review 6. Cellular strategies of axonal pathfinding.

7. Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1.

8. A spatiotemporally controllable chemical gradient generator via acoustically oscillating sharp-edge structures.

9. Spatially patterned gene expression for guided neurite extension.

Review 10. Neurotrophin regulation of neural circuit development and function.