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Literature DB >> 4939368

Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens.

Abstract

The possibility that a rat alloantiserum DA anti-Lewis possesses similar recognition structures for Lewis transplantation antigens, as do DA immunocompetent cells, was investigated by raising an antiserum against this alloantiserum in (Lewis x DA)F(1) hosts. This antiserum, as well as one provoked by injecting DA lymphoid cells, was active against recognition structures for Lewis antigens of DA immunocompetent cells. The anti-(DA anti-Lewis) antiserum displayed the same degree of specificity as was found previously for anti-recognition structure sera prepared by injecting parental strain lymphoid cells into F(1) hosts. Since the activities of antisera raised against cell-bound receptors or against the antigen-binding region of an immunoglobulin were indistinguishable, it was concluded that the functional part of cell-associated receptors might be structurally similar to the variable portion of an immunoglobulin.

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Year: 1971 PMID： 4939368 PMCID： PMC2139008 DOI： 10.1084/jem.134.5.1083

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

20 in total

8. Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells.

Authors: H Wigzell; B Andersson
Journal: J Exp Med Date: 1969-01-01 Impact factor: 14.307

3. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.

Authors: H Binz; H Wigzell
Journal: J Exp Med Date: 1975-11-01 Impact factor: 14.307

4. Cell-bound receptors for alloantigens on normal lymphocytes. I. Characterization of receptor-carrying cells by the use of antibodies to alloantibodies.

Authors: H Binz; J Lindenmann; H Wigzell
Journal: J Exp Med Date: 1974-04-01 Impact factor: 14.307

5. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.

Authors: H Binz; H Wigzell
Journal: J Exp Med Date: 1975-07-01 Impact factor: 14.307

9. Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes.

Authors: H Binz; J Lindenmann; H Wigzell
Journal: J Exp Med Date: 1974-09-01 Impact factor: 14.307

9 in total

Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens.

1. DISTRIBUTION OF PROLIFERATING DONOR CELLS IN RUNT DISEASE IN RATS.

Review 2. The genetic control of immunoglobulin synthesis.

3. Quantitative studies on antigenic recognition. II. Kinetics of the recognition event.

4. Antigen receptor molecules: inhibition by antiserum against kappa light chains.

5. Immunoglobulin determinants on the surface of mouse lymphoid cells.

Review 6. Cell selection by antigen in the immune response.

7. Further studies of histocompatibility loci in rats.

8. Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells.

9. INVASION AND DESTRUCTION OF HOMOLOGOUS KIDNEY BY LOCALLY INOCULATED LYMPHOID CELLS.

10. STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.

1. Idiotype positive T cells visualized by autoradiography and electron microscopy.

2. Life cycle patterns and their genetic control: an attempt to reconcile evolutionary and mechanistic speculation.

3. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.

4. Cell-bound receptors for alloantigens on normal lymphocytes. I. Characterization of receptor-carrying cells by the use of antibodies to alloantibodies.

5. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.

6. Inhibition of specific cell-mediated cytotoxicity by anti-T-cell receptor antibody.

7. Cellular receptors: binding of radioactively labeled anti-alloantiserum.

8. Mechanism of graft-versus-host-induced lymphadenopathy in mice. Trapping vs. proliferation.

9. Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes.