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Literature DB >> 4939150

The immunogenicity of human HL-A haplotypesas measured by skin graft survival times and mixed leukocyte reactions.

H F Seigler, F E Ward, D B Amos, M B Phaup, D L Stickel.

Abstract

The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1-12 as well as other nondefined specificities. Mixed leukocyte reactions were also studied in this series and the correlations between the mixed leukocyte reactions with skin graft survival times, individual HL-A specificities, and the number of incompatible HL-A alleles are reported. Comments concerning the interpretation and quantitation of the mixed leukocyte reactions are discussed.

Entities: Species

Mesh：

Substances：
Antigens

Year: 1971 PMID： 4939150 PMCID： PMC2138954 DOI： 10.1084/jem.133.3.411

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

11 in total

The immunogenicity of human HL-A haplotypesas measured by skin graft survival times and mixed leukocyte reactions.

1. BIOLOGICAL AND ULTRASTRUCTURAL STUDIES OF LEUCOCYTE FRACTIONS AS TRANSPLANTATION ANTIGENS IN MAN.

2. The HL-A system sub-loci and their importance in transplantation.

3. Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts.

4. Correlations of test skin grafts and renal allograft function in human subjects genotyped for HL-A.

5. Typing and immunosuppression in rats.

6. Predictive value of results of mixed leukocyte cultures for skin allograft survival in man.

7. A simple micro cytotoxicity test.

8. Skin graft rejection between subjects genotyped for HL-A.

Review 9. Heart and kidney transplantation from segregating hybrid to parental rats.

10. Quantitative assay of antigenic disparity at hl-a-the major histocompatibility locus in man.

Review 1. Tolerance induction for solid organ grafts with donor-derived hematopoietic reconstitution.

2. Three closely linked genetic systems relevant to transplantation.

3. Renal transplantation between HL-A identical donor-recipient pairs. Functional and morphological evaluation.