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Literature DB >> 4936539

Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation.

Abstract

Four patients who had received cadaveric renal allografts developed a profound and sustained leucopenia in association with a trimethoprim-sulphamethoxazole preparation. Ten other cadaveric renal allograft recipients received identical chemotherapy with no adverse effects. Statistical analysis showed that the association of leucopenia and trimethoprim-sulphamethoxazole therapy was dependent on the time after the transplantation procedure and was not related to the dosage of immunosuppressive chemotherapy or renal function.

Entities: Chemical Disease Species

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Year: 1971 PMID： 4936539 PMCID： PMC1798766 DOI： 10.1136/bmj.3.5775.610

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

8 in total

Review 1. Inhibition of folate biosynthesis and function as a basis for chemotherapy.

Authors: G H Hitchings; J J Burchall
Journal: Adv Enzymol Relat Areas Mol Biol Date: 1965

2. Serum immunosuppressive activity due to azathioprine and its relation to hepatic function after liver transplantation.

Authors: C G Mitchell; A L Eddleston; M G Smith; R Williams
Journal: Lancet Date: 1970-06-06 Impact factor: 79.321

3. Cadaveric renal transplantation. An analysis of 65 cases.

Authors: P Pletka; J R Kenyon; M Snell; S L Cohen; K Owen; J F Mowbray; B Hulme; A E Thompson; K A Porter; D A Leigh; W S Peart
Journal: Lancet Date: 1969-01-04 Impact factor: 79.321

4. Immunosuppressive powers of the antibacterial agent trimethoprim.

Authors: M W Ghilchik; A S Morris; D S Reeves
Journal: Nature Date: 1970-07-25 Impact factor: 49.962

5. Human cadaveric renal transplantation. Report of twenty cases.

Authors: J F Mowbray; S L Cohen; P B Doak; J R Kenyon; K Owen; A Percival; K A Porter; W S Peart
Journal: Br Med J Date: 1965-12-11

6. Thrombocytopenia and agranulocytosis following "septrin".

Authors: P Mohan
Journal: Practitioner Date: 1969-04

7. Neutropenia after trimethoprism-sulphamethoxazole for bronchitis.

Authors: O R McCarthy
Journal: Br Med J Date: 1969-07-12

8. Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital.

Authors: D S Reeves; M C Faiers; R E Pursell; W Brumfitt
Journal: Br Med J Date: 1969-03-01

8 in total

9 in total

1. Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats.

Authors: R G D'Antonio; D B Johnson; R E Winn; A F van Dellen; M E Evans
Journal: Antimicrob Agents Chemother Date: 1986-02 Impact factor: 5.191

Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation.

Review 1. Inhibition of folate biosynthesis and function as a basis for chemotherapy.

2. Serum immunosuppressive activity due to azathioprine and its relation to hepatic function after liver transplantation.

3. Cadaveric renal transplantation. An analysis of 65 cases.

4. Immunosuppressive powers of the antibacterial agent trimethoprim.

5. Human cadaveric renal transplantation. Report of twenty cases.

6. Thrombocytopenia and agranulocytosis following "septrin".

7. Neutropenia after trimethoprism-sulphamethoxazole for bronchitis.

8. Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital.

1. Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats.

2. Transient erythroid hypoplasia in a patient on long-term co-trimoxazole therapy.

3. Megaloblastic anaemia due to trimethoprim-sulphamethoxazole therapy in uraemia.

4. Toxicity of co-trimoxazole in nutritional haematinic deficiency.

Review 5. Problems with immunosuppressive agents in renal disease.

6. Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.

7. Renal transplantation: an analysis of 33 cases.

8. Suppression of thymidine uptake of human lymphocytes by co-trimoxazole.

9. Co-trimoxazole and azathioprine: a safe combination.