Literature DB >> 4934374

Comparative double-blind trial of cephalexin and ampicillin in treatment of urinary infections.

J A Davies, J E Strangeways, R G Mitchell, L J Beilin, J G Ledingham, J M Holt.   

Abstract

Cephalexin was compared with ampicillin in the treatment of urinary tract infections by a random double-blind technique. Both drugs were found to be equally effective. In 21 out of 31 patients treated with cephalexin and in 20 out of 31 treated with ampicillin the urine was sterile three weeks after starting therapy. The bacteriological findings at one and eight weeks were also similar in both groups. No serious adverse reactions were attributable to cephalexin, which seemed to be tolerated rather better than ampicillin.

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Year:  1971        PMID: 4934374      PMCID: PMC1798560          DOI: 10.1136/bmj.3.5768.215

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  6 in total

1.  EFFECTIVENESS OF AMPICILLIN AGAINST GRAM-NEGATIVE BACTERIA. IN VITRO AND IN VIVO STUDIES OF A NEW ANTIBIOTIC.

Authors:  K N ANDERSON; R P KENNEDY; J J PLORDE; J A SHULMAN; R G PETERSDORF
Journal:  JAMA       Date:  1964-02-22       Impact factor: 56.272

2.  Cephalexin: microbiological effects and pharmacologic parameters in man.

Authors:  B R Meyers; K Kaplan; L Weinstein
Journal:  Clin Pharmacol Ther       Date:  1969 Nov-Dec       Impact factor: 6.875

3.  Cephalexin: in vitro bacterial susceptibility, absorption in volunteers, and antibacterial activity of sera and urine.

Authors:  R L Perkins; H N Carlisle; S Saslaw
Journal:  Am J Med Sci       Date:  1968-08       Impact factor: 2.378

4.  Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic.

Authors:  P E Gower; C H Dash
Journal:  Br J Pharmacol       Date:  1969-11       Impact factor: 8.739

5.  Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital.

Authors:  D S Reeves; M C Faiers; R E Pursell; W Brumfitt
Journal:  Br Med J       Date:  1969-03-01

6.  Cephalexin, a new orally absorbed cephalosporin antibiotic.

Authors:  W E Wick
Journal:  Appl Microbiol       Date:  1967-07
  6 in total
  2 in total

Review 1.  Urinary tract infection: some recent concepts.

Authors:  R R Bailey
Journal:  Can Med Assoc J       Date:  1972-08-19       Impact factor: 8.262

Review 2.  Cephalexin: a review of its antibacterial, pharmacological and therapeutic properties.

Authors:  T M Speight; R N Brogden; G S Avery
Journal:  Drugs       Date:  1972       Impact factor: 9.546

  2 in total

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