Literature DB >> 4934072

Biochemical bases for the antimetabolite action of L-serine hydroxamate.

T Tosa, L I Pizer.   

Abstract

The amino acid analogue l-serine hydroxamate, which is bacteriostatic for Escherichia coli, has been shown to inhibit protein synthesis. The antimetabolite is a competitive inhibitor of seryl-transfer ribonucleic acid (tRNA) synthetase with a K(i) value of 30 mum. Mutants resistant to l-serine hydroxamate have been selected, and three were shown to have seryl-tRNA synthetases with increased K(i) values. One mutant contains a 3-phosphoglycerate dehydrogenase which is insensitive to inhibition by l-serine.

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Year:  1971        PMID： 4934072      PMCID： PMC248741          DOI： 10.1128/jb.106.3.972-982.1971

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  18 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase.

Authors:  E Sugimoto; L I Pizer
Journal:  J Biol Chem       Date:  1968-05-10       Impact factor: 5.157

3.  The divergence in reactivity of aminoacyl transfer ribonucleic acid synthetases of Escherichia coli with hydroxylamine.

Authors:  D I Hirsh; F Lipmann
Journal:  J Biol Chem       Date:  1968-11-10       Impact factor: 5.157

4.  Beta-aspartylhydroxamic acid: its action as a feedback inhibitor and a repressor of asparagine synthetase in Lactobacillus arabinosus.

Authors:  S J Norton; Y T Chen
Journal:  Arch Biochem Biophys       Date:  1969-02       Impact factor: 4.013

5.  Abortive infection of Escherichia coli strain W by T2 bacteriophage.

Authors:  H S Smith; L I Pizer
Journal:  J Mol Biol       Date:  1968-10-14       Impact factor: 5.469

6.  Purification and properties of seryl transfer ribonucleic acid synthetase from Escherichia coli.

Authors:  J R Katze; W Konigsberg
Journal:  J Biol Chem       Date:  1970-03-10       Impact factor: 5.157

7.  On the recognition of serine transfer RNA's specific for unrelated codons by the same seryl-transfer RNA synthetase.

Authors:  G Sundharadas; J R Katze; D Söll; W Konigsberg; P Lengyel
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

8.  End product control of amino acid synthesis by cultured human cells.

Authors:  H Eagle; C L Washington; M Levy
Journal:  J Biol Chem       Date:  1965-10       Impact factor: 5.157

9.  Serine requirement in leukemic and normal blood cells.

Authors:  J D Regan; N Vodopick; S Takeda; W H Lee; F M Faulcon
Journal:  Science       Date:  1969-03-28       Impact factor: 47.728

10.  Isolation and partial characterization of Escherichia coli mutants with altered glycyl transfer ribonucleic acid synthetases.

Authors:  W R Folk; P Berg
Journal:  J Bacteriol       Date:  1970-04       Impact factor: 3.490
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  69 in total

1.  RelE, a global inhibitor of translation, is activated during nutritional stress.

Authors:  S K Christensen; M Mikkelsen; K Pedersen; K Gerdes
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

2.  Regulation of the Escherichia coli rrnB P2 promoter.

Authors:  Heath D Murray; J Alex Appleman; Richard L Gourse
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

3.  Null mutation of HvrA compensates for loss of an essential relA/spoT-like gene in Rhodobacter capsulatus.

Authors:  Shinji Masuda; Carl E Bauer
Journal:  J Bacteriol       Date:  2004-01       Impact factor: 3.490

4.  Differential responses of Bacillus subtilis rRNA promoters to nutritional stress.

Authors:  Walied Samarrai; David X Liu; Ann-Marie White; Barbara Studamire; Jacob Edelstein; Anita Srivastava; Russell L Widom; Rivka Rudner
Journal:  J Bacteriol       Date:  2010-11-19       Impact factor: 3.490

5.  Active transcription of rRNA operons condenses the nucleoid in Escherichia coli: examining the effect of transcription on nucleoid structure in the absence of transertion.

Authors:  Julio E Cabrera; Cedric Cagliero; Selwyn Quan; Catherine L Squires; Ding Jun Jin
Journal:  J Bacteriol       Date:  2009-04-24       Impact factor: 3.490

6.  Salmonella enterica serovar Typhimurium BipA exhibits two distinct ribosome binding modes.

Authors:  Megan A deLivron; Victoria L Robinson
Journal:  J Bacteriol       Date:  2008-07-11       Impact factor: 3.490

7.  The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli.

Authors:  Matthew F Traxler; Sean M Summers; Huyen-Tran Nguyen; Vineetha M Zacharia; G Aaron Hightower; Joel T Smith; Tyrrell Conway
Journal:  Mol Microbiol       Date:  2008-04-22       Impact factor: 3.501

8.  Glutamate excretion in Escherichia coli: dependency on the relA and spoT genotype.

Authors:  A Burkovski; B Weil; R Krämer
Journal:  Arch Microbiol       Date:  1995-07       Impact factor: 2.552

9.  Characterization of the stringent response and rel(Bbu) expression in Borrelia burgdorferi.

Authors:  Julia Bugrysheva; Elena Y Dobrikova; Marina L Sartakova; Melissa J Caimano; Thomas J Daniels; Justin D Radolf; Henry P Godfrey; Felipe C Cabello
Journal:  J Bacteriol       Date:  2003-02       Impact factor: 3.490

10.  The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance.

Authors:  Malika Khakimova; Heather G Ahlgren; Joe J Harrison; Ann M English; Dao Nguyen
Journal:  J Bacteriol       Date:  2013-03-01       Impact factor: 3.490
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