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Literature DB >> 4933388

Combined use of clofibrate and cholestyramine or DEAE sephadex in hypercholesterolaemia.

Abstract

A comparison was made of the effect of DEAE (diethylaminoethyl) Sephadex (an anion exchange resin) and cholestyramine (Questran) with and without the addition of clofibrate in normal and hypercholesterolaemic patients. DEAE Sephadex (12-15 g/day) alone appeared to be as effective as cholestyramine in lowering the plasma cholesterol by 12-15%. Clofibrate acted synergistically with DEAE Sephadex and increased the activity of the latter by over twofold. This combination proved superior to that of clofibrate and cholestyramine and has the greatest potential use in the treatment of type II pattern hyperlipoproteinaemia.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1971 PMID： 4933388 PMCID： PMC1800097 DOI： 10.1136/bmj.3.5765.25

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

6 in total

1. A SEMIAUTOMATED PROCEDURE FOR THE DETERMINATION OF TRIGLYCERIDES IN SERUM.

Authors: H B LOFLAND
Journal: Anal Biochem Date: 1964-12 Impact factor: 3.365

2. CHOLESTYRAMINE RESIN THERAPY FOR HYPERCHOLESTEREMIA: CLINICAL AND METABOLIC STUDIES.

Authors: S A HASHIM; T B VANITALLIE
Journal: JAMA Date: 1965-04-26 Impact factor: 56.272

3. A revision of the Schoenheimer-Sperry method for cholesterol determination.

Authors: W M SPERRY; M WEBB
Journal: J Biol Chem Date: 1950-11 Impact factor: 5.157

Review 4. Fat transport in lipoproteins--an integrated approach to mechanisms and disorders.

Authors: D S Fredrickson; R I Levy; R S Lees
Journal: N Engl J Med Date: 1967-01-19 Impact factor: 91.245

5. Hypolipidemic effects of orally administered dextran and cellulose anion exchangers in cockerels and dogs.

Authors: T M Parkinson
Journal: J Lipid Res Date: 1967-01 Impact factor: 5.922

6. Turnover of plasma cholesterol in man.

Authors: D S Goodman; R P Noble
Journal: J Clin Invest Date: 1968-02 Impact factor: 14.808

6 in total

4 in total

Combined use of clofibrate and cholestyramine or DEAE sephadex in hypercholesterolaemia.

1. A SEMIAUTOMATED PROCEDURE FOR THE DETERMINATION OF TRIGLYCERIDES IN SERUM.

2. CHOLESTYRAMINE RESIN THERAPY FOR HYPERCHOLESTEREMIA: CLINICAL AND METABOLIC STUDIES.

3. A revision of the Schoenheimer-Sperry method for cholesterol determination.

Review 4. Fat transport in lipoproteins--an integrated approach to mechanisms and disorders.

5. Hypolipidemic effects of orally administered dextran and cellulose anion exchangers in cockerels and dogs.

6. Turnover of plasma cholesterol in man.

1. Treatment of hyperlipoproteinaemia type II A with a new anion exchange resin secholex.

Review 2. Hypolipaemic drugs and coronary heart disease.

3. [Drug treatment of primary hyperlipoproteinemia (author's transl)].

4. Gemfibrozil in the treatment of resistant familial hypercholesterolaemia and type III hyperlipoproteinaemia.