Literature DB >> 493334

Etomidate and plasma esterase activity in man and experimental animals.

R Calvo, R Carlos, S Erill.   

Abstract

No hydrolysis of etomidate in plasma in vitro was detected in samples from man, horse, cow, sheep, guinea pig or white rabbit. Brown rabbits showed a moderate degree of hydrolysis and it was marked in plasma from Wistar rats. In this species, a single enzyme, an alliesterase, participated in the hydrolysis in plasma. Etomidate did not interfere with the hydrolysis of procaine by plasma pseudocholinesterase in man.

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Year:  1979        PMID： 493334     DOI： 10.1159/000137268

Source DB:  PubMed          Journal:  Pharmacology        ISSN： 0031-7012            Impact factor:   2.547


  7 in total

1.  Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.

Authors:  Ervin Pejo; Yan Feng; Wei Chao; Joseph F Cotten; Ri Le Ge; Douglas E Raines
Journal:  Crit Care Med       Date:  2012-01       Impact factor: 7.598

2.  Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.

Authors:  Joseph F Cotten; Ri Le Ge; Natalie Banacos; Ervin Pejo; S Shaukat Husain; James H Williams; Douglas E Raines
Journal:  Anesthesiology       Date:  2011-10       Impact factor: 7.892

3.  Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats.

Authors:  Ervin Pejo; Rile Ge; Natalie Banacos; Joseph F Cotten; S Shaukat Husain; Douglas E Raines
Journal:  Anesthesiology       Date:  2012-05       Impact factor: 7.892

Review 4.  Clinical pharmacokinetics of the newer intravenous anaesthetic agents.

Authors:  P J Davis; D R Cook
Journal:  Clin Pharmacokinet       Date:  1986 Jan-Feb       Impact factor: 6.447

5.  Procaine hydrolysis defect in uraemia does not appear to be due to carbamylation of plasma esterases.

Authors:  R Calvo; R Carlos; S Erill
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

6.  Development of [18F]FAMTO: A novel fluorine-18 labelled positron emission tomography (PET) radiotracer for imaging CYP11B1 and CYP11B2 enzymes in adrenal glands.

Authors:  Salvatore Bongarzone; Filippo Basagni; Teresa Sementa; Nisha Singh; Caleb Gakpetor; Vincent Faugeras; Jayanta Bordoloi; Antony D Gee
Journal:  Nucl Med Biol       Date:  2018-11-09       Impact factor: 2.408

7.  Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.

Authors:  Rile Ge; Ervin Pejo; Joseph F Cotten; Douglas E Raines
Journal:  Crit Care       Date:  2013-01-30       Impact factor: 9.097
  7 in total

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