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Literature DB >> 4928009

Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.

Abstract

Two strains with mutations in the first structural gene of the histidine operon of Salmonella typhimurium were characterized. (The first structural gene specifies the first enzyme of histidine biosynthesis, phosphoribosyltransferase, which is sensitive to feedback inhibition by histidine.) One mutation, hisG3934, results in a phosphoribosyltransferase which is no longer sensitive to feedback inhibition by histidine but is instead subject to inhibition by aspartic acid. The other mutation, hisG3935, allows the histidine operon to be partially repressed by several amino acids, including aspartic acid. Analysis of hisG3935 is consistent with the hypothesis that phosphoribosyltransferase is directly involved in the regulation of the histidine operon.

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Year: 1971 PMID： 4928009 PMCID： PMC248666 DOI： 10.1128/jb.106.1.227-237.1971

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

24 in total

1. Histidine regulatory mutants in Salmonella typhiumium. VI. Dominance studies.

Authors: G R Fink; J R Roth
Journal: J Mol Biol Date: 1968-05-14 Impact factor: 5.469

2. Translation and polarity in the histidine operon. II. Polarity in the histidine operon.

Authors: G R Fink; R G Martin
Journal: J Mol Biol Date: 1967-11-28 Impact factor: 5.469

3. Repression of the histidine operon: effect of the first enzyme on the kinetics of repression.

Authors: J S Kovach; M A Berberich; P Venetianer; R F Goldberger
Journal: J Bacteriol Date: 1969-03 Impact factor: 3.490

4. Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.

Authors: J R Roth; D N Antón; P E Hartman
Journal: J Mol Biol Date: 1966-12-28 Impact factor: 5.469

5. Cold-sensitive mutants of Escherichia coli resulting from increased feedback inhibition.

Authors: G A O'Donovan; J L Ingraham
Journal: Proc Natl Acad Sci U S A Date: 1965-08 Impact factor: 11.205

6. Translational control of gene expression.

Authors: A L Cline; R M Bock
Journal: Cold Spring Harb Symp Quant Biol Date: 1966

7. A phage P22 gene controlling integration of prophage.

Authors: H O Smith; M Levine
Journal: Virology Date: 1967-02 Impact factor: 3.616

8. Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): inhibition of an enzyme of histidine biosynthesis.

Authors: J L Hilton; P C Kearney; B N Ames
Journal: Arch Biochem Biophys Date: 1965-12 Impact factor: 4.013

9. Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants.

Authors: G R Fink; T Klopotowski; B N Ames
Journal: J Mol Biol Date: 1967-11-28 Impact factor: 5.469

10. Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.

Authors: D F Silbert; G R Fink; B N Ames
Journal: J Mol Biol Date: 1966-12-28 Impact factor: 5.469

10 in total

1. trans-Recessive mutation in the first structural gene of the histidine operon that results in constitutive expression of the operon.

Authors: M Meyers; M Levinthal; R F Goldberger
Journal: J Bacteriol Date: 1975-12 Impact factor: 3.490

2. Specific binding of the first enzyme for histidine biosynthesis to the DNA of histidine operon.

Authors: M Meyers; F Blasi; C B Bruni; R G Deeley; J S Kovach; M Levinthal; K P Mullinix; T Vogel; R F Goldberger
Journal: Nucleic Acids Res Date: 1975-11 Impact factor: 16.971

3. Biochemical-genetic study of the first enzyme of histidine biosynthesis in Salmonella typhimurium: substrate and feedback binding regions.

Authors: V J Wainscott; J J Ferretti
Journal: J Bacteriol Date: 1978-01 Impact factor: 3.490

Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.

1. Histidine regulatory mutants in Salmonella typhiumium. VI. Dominance studies.

2. Translation and polarity in the histidine operon. II. Polarity in the histidine operon.

3. Repression of the histidine operon: effect of the first enzyme on the kinetics of repression.

4. Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.

5. Cold-sensitive mutants of Escherichia coli resulting from increased feedback inhibition.

6. Translational control of gene expression.

7. A phage P22 gene controlling integration of prophage.

8. Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): inhibition of an enzyme of histidine biosynthesis.

9. Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants.

10. Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.

1. trans-Recessive mutation in the first structural gene of the histidine operon that results in constitutive expression of the operon.

2. Specific binding of the first enzyme for histidine biosynthesis to the DNA of histidine operon.

3. Biochemical-genetic study of the first enzyme of histidine biosynthesis in Salmonella typhimurium: substrate and feedback binding regions.

Review 4. Precursor pools and endogenous control of enzyme synthesis and activity in biosynthetic pathways.

Review 5. Linkage map of Salmonella typhimurium, edition IV.

6. Derepression and repression of the histidine operon: role of the feedback site of the first enzyme.

7. Histidine production by a regulatory mutant of Streptomyces coelicolor.

8. Multivalent repression of aspartic semialdehyde dehydrogenase in Escherichia coli K-12.

9. Histidine mutants requiring adenine: selection of mutants with reduced hisG expression in Salmonella typhimurium.

10. tyrR, a regulatory gene of tyrosine biosynthesis in Salmonella typhimurium.