Possible complications secondary to cryotherapy.

Various complications are possible with cryosurgery that the cryosurgeon should be aware of. These include technical problems with the use of liquid nitrogen, skin temperature monitoring, improper patient selection, immediate secondary complications including hyperemia, erythema, bullae formation and edema, and long-term complications including depigmentation, pseudoepitheliomatous hyperplasia, loss of lashes and meibomian glands, lid deformities, scar formation, and destruction of the lacrimal system. Ocular damage has occurred following treatment of conjunctival and corneal lesions, however, not in the treatment of eyelid lesions.