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Literature DB >> 4925514

Clinical trial of malaria prophylaxis in tropical splenomegaly syndrome.

P C Stuiver, J L Ziegler, J B Wood, R H Morrow, M S Hutt.

Abstract

A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.

Entities: Disease Species

Mesh：

Substances：
Chloroquine

Year: 1971 PMID： 4925514 PMCID： PMC1795094 DOI： 10.1136/bmj.1.5746.426

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

12 in total

1. Serum immunoglobulin levels in tropical splenomegaly syndrome in New Guinea.

Authors: J V Wells
Journal: Clin Exp Immunol Date: 1968-11 Impact factor: 4.330

Review 2. The tropical splenomegaly syndrome.

Authors: W R Pitney
Journal: Trans R Soc Trop Med Hyg Date: 1968 Impact factor: 2.184

3. Splenectomy in cases of gross splenomegaly. An account of 70 cases from Lira Hospital, Uganda.

Authors: T Paliwoda; M S Hutt
Journal: East Afr Med J Date: 1968-01

4. Serial liver biopsies in big slpeen disease.

Authors: M N Lowenthal; M S Hutt
Journal: East Afr Med J Date: 1968-03

5. Tropical splenomegaly syndrome: long-term proguanil therapy correlated with spleen size, serum IgM, and lymphocyte transformation.

Authors: A S Sagoe
Journal: Br Med J Date: 1970-08-15

6. Splenomegaly in the tropics.

Authors: P D Marsden; P J Hamilton
Journal: Br Med J Date: 1969-01-11

7. Anaemia in pregnancy associated with "big spleen disease".

Authors: P J Hamilton; D A Gebbie; M S Hutt; F Lothe; N E Wilks
Journal: Br Med J Date: 1966-09-03

8. Biometric study of spleen- and liver-weights in Africans and Europeans, with special reference to endemic malaria.

Authors: L J BRUCE-CHWATT
Journal: Bull World Health Organ Date: 1956 Impact factor: 9.408

9. Idiopathic tropical splenomegaly syndrome in Ibadan.

Authors: E J Watson-Williams; N C Allan
Journal: Br Med J Date: 1968-12-28

10. Splenomegaly in New Guinea.

Authors: P D Marsden; D H Connor; A Voller; A Kelly; F D Schofield; M S Hutt
Journal: Bull World Health Organ Date: 1967 Impact factor: 9.408

15 in total

1. Infection-induced anaemia: a cross-sectional study of 14,636 German travellers aged 20-49 years.

Authors: K-H Herbinger; M Metzner; V Schmidt; M Beissner; H D Nothdurft; F von Sonnenburg; T Löscher
Journal: Infection Date: 2013-09-08 Impact factor: 3.553

2. Tropical splenomegaly, sickle-cell trait, and P. falciparum infection.

Authors: D I Evans; P M Reddy; B Wolman
Journal: Br Med J Date: 1972-01-22

3. Tropical splenomegaly, sickle-cell trait, and P. falciparum infection.

Authors: D I Evans; P M Reddy; B Wolman
Journal: Br Med J Date: 1972-04-29

4. Tropical splenomegaly, sickle cell trait, and P. falciparum infection.

Authors: M Janosi
Journal: Br Med J Date: 1972-03-04

5. Familial cases of endomyocardial fibrosis in Uganda.

Authors: A K Patel; J L Ziegler; P G D'Arbela; K Somers
Journal: Br Med J Date: 1971-11-06

6. Cryoglobulinaemia in tropical splenomegaly syndrome.

Authors: J L Ziegler
Journal: Clin Exp Immunol Date: 1973-09 Impact factor: 4.330

7. Tropical splenomegaly syndrome in Zambia: further observations and effects of cycloguanil and proguanil.

Authors: M N Lowenthal; E C O'Riordan; M S Hutt
Journal: Br Med J Date: 1971-02-20

8. Tropical splenomegaly syndrome in a Rwandan kindred in Uganda.

Authors: J L Ziegler; P C Stuiver
Journal: Br Med J Date: 1972-07-08

Review 9. The treatment of malaria.

Authors: A P Hall
Journal: Br Med J Date: 1976-02-07

10. Relapses after withdrawal of proguanil treatment in tropical splenomegaly syndrome.

Authors: A S David-West
Journal: Br Med J Date: 1974-08-24