Literature DB >> 4921478

Sequential translation of trinucleotide codons for peptide bond formation, translocation, and termination.

R K Tompkins.   

Abstract

The addition of GUA, valyl-tRNA, T factor, GTP, and ethanol to reactions containing fMet-tRNA.AUG.ribosome intermediate results in the synthesis of fMet-valyl-tRNA which can be translocated if G factor is also present. The translocated peptidyl-tRNA can interact with puromycin to form fMet-Val-puromycin. Release of fMet-valine can also take place after translocation if a terminator trinucleotide and its specific release factor are present.

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Year:  1970        PMID： 4921478      PMCID： PMC335801          DOI： 10.1073/pnas.66.4.1164

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics.

Authors:  N Tanaka; T Kinoshita; H Masukawa
Journal:  Biochem Biophys Res Commun       Date:  1968-02-15       Impact factor: 3.575

2.  Separation of three microbial amino acid polymerization factors.

Authors:  J Lucas-Lenard; F Lipmann
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

3.  Stepwise synthesis of a tripeptide.

Authors:  A L Haenni; J Lucas-Lenard
Journal:  Proc Natl Acad Sci U S A       Date:  1968-12       Impact factor: 11.205

4.  Release factors differing in specificity for terminator codons.

Authors:  E Scolnick; R Tompkins; T Caskey; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

5.  Studies on the formation of transfer ribonucleic acid-ribosome complexes. 3. The formation of peptide bonds by ribosomes in the absence of supernatant enzymes.

Authors:  S Pestka
Journal:  J Biol Chem       Date:  1968-05-25       Impact factor: 5.157

6.  Protein synthesis: uncoupling of polymerization from template control.

Authors:  R E Monro
Journal:  Nature       Date:  1969-08-30       Impact factor: 49.962

7.  Initiation and protein synthesis: translation of di- and tri-codon messengers.

Authors:  R W Erbe; P Leder
Journal:  Biochem Biophys Res Commun       Date:  1968-06-10       Impact factor: 3.575

8.  Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin.

Authors:  P Leder; H Bursztyn
Journal:  Biochem Biophys Res Commun       Date:  1966-10-20       Impact factor: 3.575

9.  Studies on the formation of trensfer ribonucleic acid-ribosome complexes. V. On the function of a soluble transfer factor in protein synthesis.

Authors:  S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

10.  Sequential translation of trinucleotide codons for the initiation and termination of protein synthesis.

Authors:  C T Caskey; R Tompkins; E Scolnick; T Caryk; M Nirenberg
Journal:  Science       Date:  1968-10-04       Impact factor: 47.728
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