Literature DB >> 4921284

Hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone in treatment of hypertension.

A Amery, M Verstraete, H Bossaert, G Verstreken.   

Abstract

In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during the methyldopa phase.

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Year:  1970        PMID： 4921284      PMCID： PMC1819951          DOI： 10.1136/bmj.4.5732.392

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  7 in total

1.  ALPHA-METHYLDOPA AND HYDROCHLOROTHIAZIDE. A CONTROLLED STUDY OF THEIR COMPARATIVE EFFECTIVENESS AS ANTIHYPERTENSIVE AGENTS.

Authors:  J M COLWILL; A M DUTTON; J MORRISSEY; P N YU
Journal:  N Engl J Med       Date:  1964-10-01       Impact factor: 91.245

2.  METHYLDOPA AND HYDROCHLOROTHIAZIDE IN PRIMARY HYPERTENSION: CONTROLLED CLINICAL TRIAL OF DRUGS SINGLY AND IN COMBINATION.

Authors:  W R WILSON; R OKUN; L TETREAULT
Journal:  JAMA       Date:  1963-09-14       Impact factor: 56.272

3.  Clonidine.

Authors:  Y K Seedat; E I Vawda; S Mitha; R Ramasar
Journal:  Lancet       Date:  1969-09-13       Impact factor: 79.321

4.  Pharmacodynamic effects of a new antihypertensive drug, Catapres (ST-155).

Authors:  G Onesti; A B Schwartz; K E Kim; C Swartz; A N Brest
Journal:  Circulation       Date:  1969-02       Impact factor: 29.690

5.  [Clinical studies with the new antihypertensive agent Catapresan].

Authors:  K Jüngling
Journal:  Med Welt       Date:  1968-09-28

6.  Clinical observations on a new antihypertensive drug, 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride.

Authors:  G Smet; S W Hoobler; S Sanbar; S Julis
Journal:  Am Heart J       Date:  1969-04       Impact factor: 4.749

7.  Co-operative clinical trial of alpha-methyldopa. 3. Double-blind control comparison of alpha-methyldopa and chlorothiazide, and chlorothiazide and rauwolfia.

Authors:  W M Smith; B Bachman; J G Galante; E G Hanowell; W P Johnson; C E Koch; S D Korfmacher; R H Thurm; L Bromer
Journal:  Ann Intern Med       Date:  1966-10       Impact factor: 25.391
  7 in total
  3 in total

1.  Letter: Measurement of side effects of drugs.

Authors: 
Journal:  Br Med J       Date:  1974-07-27

2.  Home versus clinic blood pressure measurements.

Authors:  R F Gillum; N Etemadi; J R Boen; J Kebede; P Anderson; R J Prineas
Journal:  J Natl Med Assoc       Date:  1982-06       Impact factor: 1.798

Review 3.  Using fixed-dose combination therapies to achieve blood pressure goals.

Authors:  Steven G Chrysant
Journal:  Clin Drug Investig       Date:  2008       Impact factor: 2.859
  3 in total

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