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Literature DB >> 4920413

A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide.

Abstract

The haematological effects of long-term treatment for three months with a combination of trimethoprim and sulphamethoxazole were studied in 10 cases of chronic bronchitis. Trimethoprim selectively inhibits dihydrofolate reductase in bacteria but not in man. Only minor effects on folate metabolism were observed in nine cases, causing no clinical concern. Some degree of thrombocytopenia occurred in the tenth case which improved when folinic acid was given.

Entities: Chemical Disease Species

Mesh：

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Year: 1970 PMID： 4920413 PMCID： PMC476778 DOI： 10.1136/jcp.23.5.392

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

10 in total

1. 5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.

Authors: B ROTH; E A FALCO; G H HITCHINGS; S R BUSHBY
Journal: J Med Pharm Chem Date: 1962-11

Review 2. FOLIC ACID.

Authors: V HERBERT
Journal: Annu Rev Med Date: 1965 Impact factor: 13.739

3. Experimental nutritional folate deficiency in man.

Authors: V HERBERT
Journal: Trans Assoc Am Physicians Date: 1962

4. A spectrophotometric method for estimating formimino-glutamic and urocanic acid.

Authors: I CHANARIN; M C BENNETT
Journal: Br Med J Date: 1962-01-06

5. THE "INDUCTION" OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN.

Authors: J R Bertino; D M Donohue; B Simmons; B W Gabrio; R Silber; F M Huennekens
Journal: J Clin Invest Date: 1963-04 Impact factor: 14.808

8 in total

8. Unexpected Cardiomyopathy and Cardiac Dysfunction after Administration of Sulfadiazine-trimethoprim Medicated Diet to ICR mice (Mus musculus).

Authors: Nicole M Pach; Kerith R Luchins; Gene H Kim; George P Langan; Betty R Theriault
Journal: Comp Med Date: 2020-07-27 Impact factor: 0.982

8 in total

A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide.

1. 5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.

Review 2. FOLIC ACID.

3. Experimental nutritional folate deficiency in man.

4. A spectrophotometric method for estimating formimino-glutamic and urocanic acid.

5. THE "INDUCTION" OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN.

6. Effects of trimethoprim on folate metabolism in man.

7. Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.

8. Trimethoprim: laboratory and clinical studies.

9. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency.

10. MICROBIOLOGICAL ASSAY OF FOLIC ACID ACTIVITY IN HUMAN SERUM.

Review 1. Considerations when prescribing trimethoprim-sulfamethoxazole.

2. Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim.

3. Toxicity of co-trimoxazole in nutritional haematinic deficiency.

4. The sensitivity of Pseudomonas pseudomallei to trimethoprim and sulphamethoxazole in vitro.

5. Clinical pharmacokinetics of co-trimoxazole (trimethoprim-sulphamethoxazole).

6. Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow.

7. Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.

8. Unexpected Cardiomyopathy and Cardiac Dysfunction after Administration of Sulfadiazine-trimethoprim Medicated Diet to ICR mice (Mus musculus).