Literature DB >> 49137

[Method for determination of the bleomycin inactivating enzyme acitivity in tissues].

W E Müller, A Totsuka, R K Zahn, H Umezawa.   

Abstract

An enzyme that inactivates Bleomycin (BLM) can be extracted from tissue. The activity of this enzyme varies markedly in different tissues. In the present paper, a method is described by which the activity of the BLM-inactivating enzyme in different organs and tissues of mice can be determined. The highest activity is found in liver; lower enzyme concentrations occur in the testis, spleen, lung and brain. In skin this enzyme is almost completely missing.

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Year:  1975        PMID： 49137     DOI： 10.1007/bf00282982

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  17 in total

1.  [A preservation and preparation process for desoxyribonucleic acids and their raw materials].

Authors:  R K ZAHN; E TIESLER; A K KLEINSCHMIDT; D LANG
Journal:  Biochem Z       Date:  1962

2.  Preparation of 3'-dinucleotides from homoribopolymers by digestion with micrococcal nuclease.

Authors:  E Sulkowski; A M Odlyzko; M Laskowski
Journal:  Anal Biochem       Date:  1970-12       Impact factor: 3.365

3.  Bleomycin, a selective inhibitor of DNA-dependent DNA polymerase from oncogenic RNA viruses.

Authors:  W E Müller; Z I Yamazaki; R K Zahn
Journal:  Biochem Biophys Res Commun       Date:  1972-02-25       Impact factor: 3.575

4.  Release of free bases from deoxyribonucleic acid after reaction with bleomycin.

Authors:  C W Haidle; K K Weiss; M T Kuo
Journal:  Mol Pharmacol       Date:  1972-09       Impact factor: 4.436

5.  Selective elimination of the exonuclease activity of the deoxyribonucleic acid polymerase from Escherichia coli B by limited proteolysis.

Authors:  H Klenow; I Henningsen
Journal:  Proc Natl Acad Sci U S A       Date:  1970-01       Impact factor: 11.205

6.  RNA dependent DNA polymerase in cells of xeroderma pigmentosum.

Authors:  W E Müller; Z I Yamazaki; R K Zahn; G Brehm; G Korting
Journal:  Biochem Biophys Res Commun       Date:  1971-07-16       Impact factor: 3.575

7.  Enzymatic synthesis of deoxyribonucleic acid. XXVI. Physical and chemical studies of a homogeneous deoxyribonucleic acid polymerase.

Authors:  T M Jovin; P T Englund; L L Bertsch
Journal:  J Biol Chem       Date:  1969-06-10       Impact factor: 5.157

8.  Bleomycin treatment of the tumors of penis and scrotum.

Authors:  T Ichikawa; I Nakano; I Hirokawa
Journal:  J Urol       Date:  1969-12       Impact factor: 7.450

9.  Breaks and rejoining of DNA in cultured mammalian cells treated with bleomycin.

Authors:  T Terasima; M Yasukawa; H Umezawa
Journal:  Gan       Date:  1970-10

10.  New antibiotics, bleomycin A and B.

Authors:  H Umezawa; K Maeda; T Takeuchi; Y Okami
Journal:  J Antibiot (Tokyo)       Date:  1966-09       Impact factor: 2.649
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  2 in total

1.  Bleomycin: action on growth of oncogenic RNA viruses and on cell transformation.

Authors: 
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

2.  Therapy of solid Walker carcinosarcoma 256 with bleomycin after synchronization with hydroxyurea.

Authors:  M Volm; J Mattern; N Weber; K Wayss
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333
  2 in total

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