Literature DB >> 4909707

Effects of amphetamine derivatives on brain dopamine and noradrenaline.

G R Breese, I J Kopin, V K Weise.   

Abstract

1. Intracisternally administered metaraminol, alpha-methyl-octopamine, alpha-methyl-m-tyramine, and alpha-methyl tyramine were found to lower brain noradrenaline without having an effect on brain dopamine.2. Amphetamine, mephentermine, and norephedrine had no effect on brain catecholamines after intracisternal injection.3. There was no reduction in brain dopamine content after intracisternal injection of alpha-methyl-m-tyramine, yet the resulting brain concentration of alpha-methyl-m-tyramine was several times higher than after intraperitoneal injection of alpha-methyl-m-tyrosine, which decreased brain dopamine.4. The decreased synthesis of labelled catecholamines from (14)C-tyrosine after alpha-methyl-m-tyrosine suggested that this compound inhibits tyrosine hydroxylase in addition to its action of displacing brain amines.

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Year:  1970        PMID： 4909707      PMCID： PMC1702572          DOI： 10.1111/j.1476-5381.1970.tb10595.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  20 in total

1.  In-vivo decarboxylation of alpha-methyl DOPA and alpha-methyl metatyrosine.

Authors:  A CARLSSON; M LINDQVIST
Journal:  Acta Physiol Scand       Date:  1962-01

2.  The effects of alpha-methyl-DOPA and alpha-methyl-metatyrosine on the metabolism of norepinephrine and serotonin in vivo.

Authors:  S M HESS; R H CONNAMACHER; M OZAKI; S UDENFRIEND
Journal:  J Pharmacol Exp Ther       Date:  1961-11       Impact factor: 4.030

3.  Some central actions of 5-hydroxytryptamine and various antagonists.

Authors:  J H GADDUM; M VOGT
Journal:  Br J Pharmacol Chemother       Date:  1956-06

4.  Injections of drugs into the lateral ventricle of the cat.

Authors:  W FELDBERG; S L SHERWOOD
Journal:  J Physiol       Date:  1954-01       Impact factor: 5.182

5.  The action of sympathomimetic amines on the central nervous system and the blood sugar; relation of chemical structure to mechanism of action.

Authors:  A LEIMDORFER
Journal:  J Pharmacol Exp Ther       Date:  1950-01       Impact factor: 4.030

6.  Metabolism of normetanephrine-H3 in rat brain--identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite.

Authors:  S M Schanberg; J J Schildkraut; G R Breese; I J Kopin
Journal:  Biochem Pharmacol       Date:  1968-02       Impact factor: 5.858

7.  The rate of norepinephrine synthesis measured in vivo during short intervals; influence of adrenergic nerve impulse activity.

Authors:  G C Sedvall; V K Weise; I J Kopin
Journal:  J Pharmacol Exp Ther       Date:  1968-02       Impact factor: 4.030

8.  Evidence that the CCENTRAL ACTION OF (+)-amphetamine is mediated via catecholamines.

Authors:  L C Hanson
Journal:  Psychopharmacologia       Date:  1967

9.  Liberation of p-hydroxynorephedrine from cat spleen by sympathetic nerve stimulation after pretreatment with amphetamine.

Authors:  H Thoenen; A Hürlimann; K F Gey; W Haefely
Journal:  Life Sci       Date:  1966-09       Impact factor: 5.037

10.  Antiamphetamine effects following inhibition of tyrosine hydroxylase.

Authors:  A Weissman; B K Koe; S S Tenen
Journal:  J Pharmacol Exp Ther       Date:  1966-03       Impact factor: 4.030
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  5 in total

1.  Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.

Authors:  G R Breese; T D Traylor
Journal:  J Pharmacol Exp Ther       Date:  1970-09       Impact factor: 4.030

2.  Evidence that punctate intracerebral administration of 6-hydroxydopamine fails to produce selective neuronal degeneration. Comparison with copper sulfate and factors governing the deportment of fluids injected into brain.

Authors:  L L Butcher; S M Eastgate; G K Hodge
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

3.  Importance of the Locus coeruleus and involvement of alpha-adrenergic receptors in the post-decapitation reflex in the rat.

Authors:  B A Pappas; G R Breese; R B Mailman; R A Mueller
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

4.  Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.

Authors:  G R Breese; T D Traylor
Journal:  Br J Pharmacol       Date:  1971-05       Impact factor: 8.739

5.  A neuronal basis for the alerting action of (+)-amphetamine.

Authors:  R J Boakes; P B Bradley; J M Candy
Journal:  Br J Pharmacol       Date:  1972-07       Impact factor: 8.739
  5 in total

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