Literature DB >> 4909468

Template activity of liver chromatin increased by in vivo administration of insulin.

C R Morgan, J Bonner.   

Abstract

The hypothesis that insulin may serve as a derepressor of genetic information in the liver of diabetic rats has been tested by comparing the template activity for RNA synthesis of chromatin from liver of insulin-treated diabetic rats to that of chromatin from liver of insulin-deficient diabetic rats. The template activity of the chromatins of insulin-treated diabetic rats is found to be 28 per cent greater than that of chromatin from liver of diabetic rats not treated with insulin. Time course studies show that the template activity of liver chromatin of rats injected with a single dose of insulin reaches a peak at two hours, which is some hours before the appearance of a typical insulin-induced liver enzyme, glucokinase. We conclude that insulin derepresses genetic material of the diabetic liver genome that is repressed in the absence of insulin.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 4909468      PMCID： PMC283025          DOI： 10.1073/pnas.65.4.1077

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  INSULIN-DEPENDENT SYNTHESIS OF LIVER GLUCOKINASE IN THE RAT.

Authors:  M SALAS; E VINUELA; A SOLS
Journal:  J Biol Chem       Date:  1963-11       Impact factor: 5.157

2.  Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli.

Authors:  M CHAMBERLIN; P BERG
Journal:  Proc Natl Acad Sci U S A       Date:  1962-01-15       Impact factor: 11.205

3.  Increased template activity of liver chromatin, a result of hydrocortisone administration.

Authors:  M E Dahmus; J Bonner
Journal:  Proc Natl Acad Sci U S A       Date:  1965-11       Impact factor: 11.205

Review 4.  The statistical analysis of enzyme kinetic data.

Authors:  W W Cleland
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1967

Review 5.  Insulin and the regulation of hepatic biosynthetic activity.

Authors:  D F Steiner
Journal:  Vitam Horm       Date:  1966       Impact factor: 3.421

6.  Immunoassay of pancreatic and plasma insulin following alloxan injection of rats.

Authors:  C R Morgan; A Lazarow
Journal:  Diabetes       Date:  1965-10       Impact factor: 9.461

7.  A protein intermediary in the interaction of a hormone with the genome.

Authors:  A G Matthysse; C Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  1969-07       Impact factor: 11.205

8.  Template properties of liver chromatin.

Authors:  K Marushige; J Bonner
Journal:  J Mol Biol       Date:  1966-01       Impact factor: 5.469

9.  Some properties of a nuclear binding site of estradiol.

Authors:  H R Maurer; G R Chalkley
Journal:  J Mol Biol       Date:  1967-08-14       Impact factor: 5.469
  9 in total
  6 in total

1.  Binding of insulin to isolated nuclei.

Authors:  I D Goldfine; G J Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

2.  Effects of insulin and glucose on subcellular fractions from rat adipose tissue.

Authors:  E Pimentel; C A González; F González-Mujica
Journal:  Acta Diabetol Lat       Date:  1974 May-Jun

3.  Influence of steroid replacement therapy on rat embryos of hypophysectomised mother animals.

Authors:  E Köhler; R Berswordt-Wallrabe; W Ehmke; F Wojnorowicz
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

4.  A probable effect of diabetes mellitus on incorporation of amino acids into proteins catalyzed by isolated rat liver nuclei.

Authors:  K M Anderson
Journal:  Experientia       Date:  1971-03-15

5.  Template activity of chromatin during stimulation of cellular proliferation in human diploid fibroblasts.

Authors:  J Farber; G Rovera; R Baserga
Journal:  Biochem J       Date:  1971-04       Impact factor: 3.857

6.  Action of insulin at the nuclear envelope.

Authors:  I D Goldfine; G A Clawson; E A Smuckler; F Purrello
Journal:  Mol Cell Biochem       Date:  1982-10-01       Impact factor: 3.396
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.