| Literature DB >> 490552 |
W J Welstead, H W Moran, H F Stauffer, L B Turnbull, L F Sancilio.
Abstract
The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models.Entities:
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Year: 1979 PMID： 490552 DOI： 10.1021/jm00195a012
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446