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Literature DB >> 4902391

Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.

B Ozanne, R Benveniste, D Tipper, J Davies.

Abstract

R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-l-glucopyranosyl moiety is phosphorylated.

Entities: Chemical Species

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Year: 1969 PMID： 4902391 PMCID： PMC250215 DOI： 10.1128/jb.100.2.1144-1146.1969

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

11 in total

1. Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor.

Authors: H Umezawa; S Takasawa; M Okanishi; R Utahara
Journal: J Antibiot (Tokyo) Date: 1968-01 Impact factor: 2.649

2. Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor.

Authors: H Umezawa; M Okanishi; S Kondo; K Hamana; R Utahara; K Maeda; S Mitsuhashi
Journal: Science Date: 1967-09-29 Impact factor: 47.728

3. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.

Authors: S Okamoto; Y Suzuki
Journal: Nature Date: 1965-12-25 Impact factor: 49.962

4. Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor.

Authors: S Takasawa; R Utahara; M Okanishi; K Maeda; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1968-08 Impact factor: 2.649

5. Isolation of kanamycin and paromamine inactivated by E. coli carrying R factor.

Authors: S Kondo; M Okanishi; R Utahara; K Maeda; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1968-01 Impact factor: 2.649

6. Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.

Authors: T Yamada; D Tipper; J Davies
Journal: Nature Date: 1968-07-20 Impact factor: 49.962

7. The release of enzymes by osmotic shock from Escherichia coli in exponential phase.

Authors: N G Nossal; L A Heppel
Journal: J Biol Chem Date: 1966-07-10 Impact factor: 5.157

8. Phosphorylation and inactivation of aminoglycosidic antibiotics by E. coli carrying R factor.

Authors: K Okanishi; S Kondo; R Utahara; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1968-01 Impact factor: 2.649

9. Studies on inactivation of kanamycin and resistances of E. coli.

Authors: M Okanishi; S Kondo; Y Suzuki; S Okamoto; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1967-07 Impact factor: 2.649

10. Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.

Authors: H Umezawa; M Okanishi; R Utahara; K Maeda; S Kondo
Journal: J Antibiot (Tokyo) Date: 1967-07 Impact factor: 2.649

43 in total

1. New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron.

Authors: P V Adrian; C J Thomson; K P Klugman; S G Amyes
Journal: Antimicrob Agents Chemother Date: 2000-02 Impact factor: 5.191

2. Detection of R factors in naturally occurring Vibrio anguillarum strains.

Authors: T Aoki; S Egusa; T Arai
Journal: Antimicrob Agents Chemother Date: 1974-11 Impact factor: 5.191

3. Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9).

Authors: E Murphy
Journal: Mol Gen Genet Date: 1985

Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.

1. Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor.

2. Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor.

3. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.

4. Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor.

5. Isolation of kanamycin and paromamine inactivated by E. coli carrying R factor.

6. Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.

7. The release of enzymes by osmotic shock from Escherichia coli in exponential phase.

8. Phosphorylation and inactivation of aminoglycosidic antibiotics by E. coli carrying R factor.

9. Studies on inactivation of kanamycin and resistances of E. coli.

10. Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.

1. New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron.

2. Detection of R factors in naturally occurring Vibrio anguillarum strains.

3. Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9).

4. Genetic and molecular characterisation of some non-transferring plasmids.

5. Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.

6. Phosphorylation of kanamycin, lividomycin A, amd butirosin B by Providencia stuartii.

7. Hospital Pseudomonas aeruginosa: surveillance of resistance to gentamicin and transfer of aminoglycoside R factor.

8. Microbial transformation of antibiotics: phosphorylation of clindamycin by Streptomyces coelicolor Müller.

9. Potentiation of antibiotic bactericidal activity by normal human serum.

10. Mutations in R factors of Escherichia coli causing an increased number of R-factor copies per chromosome.