Literature DB >> 4899830

Changing sensitivity of the pubertal gonadal hypothalamic feedback mechanism in man.

H E Kulin, M M Grumbach, S L Kaplan.   

Abstract

Clomiphene citrate in doses which stimulate gonadotropin production in the adult suppresses urinary follicle stimulating hormone (FSH) excretion and plasma testosterone concentration in prepubertal children. Such results indicate that feedback between gonad and hypothalamus is operative and highly sensitive in prepubertal humans. Puberty in man, as in the rat, is accompanied by a decrease in the sensitivity of the feedback mechanism.

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Year:  1969        PMID： 4899830     DOI： 10.1126/science.166.3908.1012

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  17 in total

1.  Development of interest and enjoyment in adolescence. Part I. Attentional capacities.

Authors:  J A Hamilton
Journal:  J Youth Adolesc       Date:  1983-10

2.  Melvin M. Grumbach 1925-2016.

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Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205

3.  Adipose tissue proteomic analyses to study puberty in Brahman heifers.

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Journal:  J Anim Sci       Date:  2018-06-04       Impact factor: 3.159

Review 4.  Some physiological and clinical aspects of puberty.

Authors:  H K Visser
Journal:  Arch Dis Child       Date:  1973-03       Impact factor: 3.791

5.  Excretion of individual adrenocortical steroids in obese children.

Authors:  D C Savage; C C Forsyth; J Cameron
Journal:  Arch Dis Child       Date:  1974-12       Impact factor: 3.791

Review 6.  Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity.

Authors:  Robert L Rosenfield; Brian Bordini
Journal:  Brain Res       Date:  2010-09-25       Impact factor: 3.252

7.  Survival and growth in a woman with untreated hypothalamic panhypopituitarism of 21 years' duration.

Authors:  G Tolis; S Cruess; M Goldstein; H G Friesen; J G Rochefort
Journal:  Can Med Assoc J       Date:  1974-09-21       Impact factor: 8.262

8.  Suppression of urinary and plasma follicle-stimulating hormone by exogenous estrogens in prepubertal and pubertal children.

Authors:  R P Kelch; S L Kaplan; M M Ghumbach
Journal:  J Clin Invest       Date:  1973-05       Impact factor: 14.808

9.  Functional evaluation of prolactin secretion in patients with hypothalamic-pituitary disorders.

Authors:  G Tolis; M Goldstein; H G Friesen
Journal:  J Clin Invest       Date:  1973-04       Impact factor: 14.808

Review 10.  Kisspeptin and puberty in mammals.

Authors:  Ei Terasawa; Kathryn A Guerriero; Tony M Plant
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622
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