Literature DB >> 48948

Why are ovarian teratomas benign whilst teratomas of the testis are malignant?

P A Riley, P M Sutton.   

Abstract

A mechanism is suggested to account for the fact that most ovarian teratomas are benign (dermoid cysts) whereas testicular teratomas are almost always malignant. The mechanism advanced assumes that malignancy is cause by a recessive mutation, and then shows that the known facts of germ-cell development will produce the homozygous (malignant) state in the male but the heterozygous counterpart in the female. It is proposed that the benign nature of ovarian teratomas is a reflection of this heterozygous genotype.

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Year:  1975        PMID: 48948     DOI: 10.1016/s0140-6736(75)92265-5

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  4 in total

1.  Aetiological factors in childhood neoplasia.

Authors:  C L Berry
Journal:  J Clin Pathol       Date:  1976-11       Impact factor: 3.411

Review 2.  Developmental pathology.

Authors:  R P Bolande
Journal:  Am J Pathol       Date:  1979-03       Impact factor: 4.307

3.  The origin of ovarian teratomas.

Authors:  J M Parrington; L F West; S Povey
Journal:  J Med Genet       Date:  1984-02       Impact factor: 6.318

4.  DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors.

Authors:  James F Amatruda; Julie A Ross; Brock Christensen; Nicholas J Fustino; Kenneth S Chen; Anthony J Hooten; Heather Nelson; Jacquelyn K Kuriger; Dinesh Rakheja; A Lindsay Frazier; Jenny N Poynter
Journal:  BMC Cancer       Date:  2013-06-27       Impact factor: 4.430

  4 in total

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