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Literature DB >> 489476

Withdrawal of chronic chlorpromazine medication: an experimental analysis.

Abstract

Approximately 50% of all institutionalized, mentally retarded adults receive psychotropic medication to control inappropriate behavior. In this study, behaviors exhibited by five retarded adults were formally observed while they were on and off medication. Each subject had been receiving chlorpromazine for six or more years prior to the start of the study. The drug was withdrawn and readministered using a double-blind B-A-B (drug placebo-drug) design. Effects were highly individualized. Some desirable behavior emerged when chlorpromazine was discontinued.

Entities: Chemical Disease

Mesh：

Substances：
Placebos
Chlorpromazine

Year: 1979 PMID： 489476 PMCID： PMC1311360 DOI： 10.1901/jaba.1979.12-159

Source DB: PubMed Journal: J Appl Behav Anal ISSN： 0021-8855

13 in total

1. Review of drug treatment for Down's syndrome persons.

Authors: J B Share
Journal: Am J Ment Defic Date: 1976-01

2. The psychopharmacology of phenothiazine compounds: a comparative study of the effects of chlorpromazine, promethazine, trifluoperazine, and perphenazine in normal males. II. Results and discussion.

Authors: A DIMASCIO; L L HAVENS; G L KLERMAN
Journal: J Nerv Ment Dis Date: 1963-02 Impact factor: 2.254

3. Methodological issues in psychopharmacological research: chlorpromazine--a case in point.

Authors: D Marholin; D Phillips
Journal: Am J Orthopsychiatry Date: 1976-07

4. Effects of diet and behavior therapy on social and motor behavior of retarded phenylketonuric adults: an experimental analysis.

Authors: D Marholin; R E Pohl; R M Stewart; P E Touchette; N M Townsend; E H Kolodny
Journal: Pediatr Res Date: 1978-03 Impact factor: 3.756

Review 1. Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: integration of psychological and biological theory and approach.

Authors: Noha F Minshawi; Sarah Hurwitz; Danielle Morriss; Christopher J McDougle
Journal: J Autism Dev Disord Date: 2015-06

2. Clinical behavioral pharmacology: methods for evaluating medications and contingency management.

Authors: L D Burgio; T J Page; R M Capriotti
Journal: J Appl Behav Anal Date: 1985

2 in total

Withdrawal of chronic chlorpromazine medication: an experimental analysis.

1. Review of drug treatment for Down's syndrome persons.

2. The psychopharmacology of phenothiazine compounds: a comparative study of the effects of chlorpromazine, promethazine, trifluoperazine, and perphenazine in normal males. II. Results and discussion.

3. Methodological issues in psychopharmacological research: chlorpromazine--a case in point.

4. Effects of diet and behavior therapy on social and motor behavior of retarded phenylketonuric adults: an experimental analysis.

5. Research design for analyzing drug-environment-behavior interactions.

Review 6. Pharmacologic side effects of tranquilizers and antidepressants.

7. Chlorpromazine: direct measurement of differential behavioral effect.

8. Effects of combining methylphenidate and a classroom token system in modifying hyperactive behavior.

9. Stimulus control in the classroom as a function of the behavior reinforced.

10. A behavioral-educational alternative to drug control of hyperactive children.

Review 1. Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: integration of psychological and biological theory and approach.

2. Clinical behavioral pharmacology: methods for evaluating medications and contingency management.