Literature DB >> 488919

Studies on the hydrolysis of 1-alk-1'-enyl-sn-glycero-3-phosphoethanolamine by microsomes from myelinating rat brain.

J Gunawan, M Vierbuchen, H Debuch.   

Abstract

Microsomal fractions of 14-day-old rat brain were incubated at pH 7.1 with 1-[1'-14C]-alk-1'-enyl-sn-glycero-3-phosphoethanolamine (lysoplasmalogen). 1-[1'-14C]alkenylglycerol was produced by hydrolyzing enzyme activities, which were stimulated by Mg2 and inhibited by SH-group reagents. Hydrolysis of 1-[1'-14C]alkyl-sn-glycero-3-phosphoethanolamine is very similar in this respect, but the Km value is higher in the former case. The 1-alkyl compound acts as a non-competitive inhibitor of the hydrolyzing enzyme activity described, whereas the hydrolysis of the 1-alkyl derivative is not inhibited by the 1-alkenyl compound.

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Year:  1979        PMID： 488919     DOI： 10.1515/bchm2.1979.360.2.971

Source DB:  PubMed          Journal:  Hoppe Seylers Z Physiol Chem        ISSN： 0018-4888


  7 in total

1.  Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.

Authors:  T Vartanian; T J Sprinkle; G Dawson; S Szuchet
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

2.  Fluorimetric coupled enzyme assay for lysoplasmalogenase activity in liver.

Authors:  Y Hirashima; A A Farooqui; L A Horrocks
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

3.  The YhhN protein of Legionella pneumophila is a Lysoplasmalogenase.

Authors:  Marianne S Jurkowitz; Aalapi Patel; Lai-Chu Wu; Annalise Krautwater; Douglas R Pfeiffer; Charles E Bell
Journal:  Biochim Biophys Acta       Date:  2014-11-16

4.  Turnover of phosphocholine and phosphoethanolamine in ether-phospholipids of Krebs II ascite cells.

Authors:  A E Tamer; M Record; H Chap; L Douste-Blazy
Journal:  Lipids       Date:  1985-10       Impact factor: 1.880

5.  On the phospholipid metabolism of glial cell primary cultures. III. Utilization of 1-alkenyl-glycerophosphoethanolamine (lysoplasmalogen).

Authors:  H K Illig; B Witter; H Debuch
Journal:  Neurochem Res       Date:  1982-10       Impact factor: 3.996

6.  Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.

Authors:  Lai-Chu Wu; Douglas R Pfeiffer; Elisabeth A Calhoon; Francesca Madiai; Guido Marcucci; Shujun Liu; Marianne S Jurkowitz
Journal:  J Biol Chem       Date:  2011-04-22       Impact factor: 5.157

7.  Molecular cloning, heterologous expression, and enzymatic characterization of lysoplasmalogen-specific phospholipase D from Thermocrispum sp.

Authors:  Yusaku Matsumoto; Nana Kashiwabara; Takayuki Oyama; Kazutaka Murayama; Hideyuki Matsumoto; Shin-Ich Sakasegawa; Daisuke Sugimori
Journal:  FEBS Open Bio       Date:  2016-10-17       Impact factor: 2.693
  7 in total

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