| Literature DB >> 488284 |
E Mattei, A Delpino, U Ferrini.
Abstract
Time- and dose-dependent protein synthesis inhibition takes place following exposure to high doses of dimethylnitrosamine (DMN) or diethylnitrosamine (DENA) in isolated rat hepatocytes. The ability of DENA to depress protein synthesis is 5-fold higher than that of DMN. Cells inhibited by 60 min exposure to DMN or DENA, and then incubated in a nitrosamine-free medium, regain their initial rate of protein synthesis. This recovery is faster and more complete for DENA-treated cells.Entities:
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Year: 1979 PMID： 488284 DOI： 10.1007/bf01963297
Source DB: PubMed Journal: Experientia ISSN： 0014-4754