Literature DB >> 488132

The metabolism of saddamine in man: the fate of the benzylamine moiety of saddamine.

M R Al-Ani, S G Wood, A Lawson.   

Abstract

The metabolism of 14C-saddamine radiolabelled in the benzylamine moiety has been investigated in man after oral administration. 14C-Hippuric acid was found to be the only radiolabelled urinary metabolite, the overall amount of which was equivalent to over 95% of the dose. The time taken for elimination of 50% of the dose in the urine was approximately five hours and the corresponding value for 14C-benzylamine hydrochloride was less than one hour.

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Year:  1979        PMID: 488132     DOI: 10.1007/BF03189411

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN: 0378-7966            Impact factor:   2.441


  8 in total

1.  Elimination of amines in man.

Authors:  D Richter
Journal:  Biochem J       Date:  1938-10       Impact factor: 3.857

2.  The oxidation of adrenaline and other amines.

Authors:  H Blaschko; D Richter; H Schlossmann
Journal:  Biochem J       Date:  1937-12       Impact factor: 3.857

3.  Adrenaline and amine oxidase.

Authors:  D Richter
Journal:  Biochem J       Date:  1937-11       Impact factor: 3.857

4.  The effect of para-aminobenzoic acid on the metabolism and excretion of salicylate.

Authors:  R M SALASSA; J L BOLLMAN; T J DRY
Journal:  J Lab Clin Med       Date:  1948-11

5.  The effect of oral administration of para-aminobenzoic acid on the concentration of salicylates in the blood; preliminary report.

Authors:  T J DRY; H R BUTT; C H SCHEIFLEY
Journal:  Proc Staff Meet Mayo Clin       Date:  1946-12-24

6.  Comparison of the major urinary metabolites of saddamine and aspirin using thin-layer chromatography.

Authors:  M R Al-Ani; S G Wood; A Lawson
Journal:  J Chromatogr       Date:  1978-12-11

7.  Kinetics of competitive inhibition of salicylic acid conjugation with glycine in man.

Authors:  G Levy; L P Amsel
Journal:  Biochem Pharmacol       Date:  1966-08       Impact factor: 5.858

8.  Hippuric acid excretion after benzylamine ingestion in man.

Authors:  S G Wood; M R Al-Ani; A Lawson
Journal:  Br J Ind Med       Date:  1978-08
  8 in total

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